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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
We report on six young female patients from two families who were found to have a very rare form of ovarian failure. Hypogonadism is inherited with an ocular abnormality consisting of a congenital dysplasia of the eyelids. In one family inheritance is autosomal dominant and in the other it is a de novo mutation. The patients have no other dysmorphic features and are of normal intelligence. Plasma levels of follicle-stimulating and luteinizing hormones are significantly elevated. Examination of the internal genitalia by laparoscopy was performed in four cases with ovarian biopsy in one case; the results are compatible with gonadal dysgenesis. Cytogenetic studies indicate the absence of chromosomal defects.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0334-018X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-33
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:7584707-Adolescent,
pubmed-meshheading:7584707-Blepharophimosis,
pubmed-meshheading:7584707-Child,
pubmed-meshheading:7584707-Female,
pubmed-meshheading:7584707-Follicle Stimulating Hormone,
pubmed-meshheading:7584707-Humans,
pubmed-meshheading:7584707-Hypogonadism,
pubmed-meshheading:7584707-Karyotyping,
pubmed-meshheading:7584707-Luteinizing Hormone,
pubmed-meshheading:7584707-Male,
pubmed-meshheading:7584707-Mutation,
pubmed-meshheading:7584707-Ovary,
pubmed-meshheading:7584707-Pedigree
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pubmed:articleTitle |
Familial blepharophimosis: an uncommon marker of ovarian dysgenesis.
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pubmed:affiliation |
Service d'Endocrinologie Pédiatrique Hôpital Debrousse, Lyon, France.
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pubmed:publicationType |
Journal Article,
Case Reports
|