Linked Life Data

7583174

Source:http://linkedlifedata.com/resource/pubmed/id/7583174

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-12-12
pubmed:abstractText
Antioxidant therapies are currently undergoing clinical trials to determine their benefit in a number of diseases seen in the critical care unit. It is particularly likely that their use will become standard therapy in a number of situations in which there is reperfusion injury following an ischemic episode. During the lag time from the conception of antioxidant interventions to their introduction into clinical practice, our understanding of how oxidant injuries are mediated has changed considerably. This understanding has allowed the development of more rational approaches to antioxidant therapy while exposing the limitations of some of the approaches currently being evaluated in a clinical setting. In addition, some existing therapeutic agents have previously unrecognized antioxidant and pro-oxidant effects. An inherent requirement of an effective antioxidant therapy is that such therapy is effective against the radicals being generated, and that sufficient quantities of the antioxidants used reach all sites of radical generation in time to limit tissue injury. Recent observations suggest that few, if any, of the currently known individual antioxidants can adequately meet these goals. However, combination therapy, or the development of synthetic compounds that can combine the properties of current antioxidants, may come close.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1063-7389
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
330-41
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Antioxidant therapy in critical care medicine.
pubmed:affiliation
Medical Research Council of Canada Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto, ON, Canada.
pubmed:publicationType
Journal Article, Review