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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1995-12-7
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pubmed:abstractText |
The polypeptide anthopleurin-B (AP-B) is one of a number of related toxins produced by sea anemones. AP-B delays inactivation of the voltage-gated sodium channel of excitable tissue. In the mammalian heart, this effect is manifest as an increase in the force of contraction. As a result, there is interest in exploiting the anthopleurins as lead compounds in the design of novel cardiac stimulants. Essential to this endeavour is a high-resolution solution structure of the molecule describing the positions of functionally important side chains.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0969-2126
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
791-803
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7582896-Amino Acid Sequence,
pubmed-meshheading:7582896-Animals,
pubmed-meshheading:7582896-Cardiotonic Agents,
pubmed-meshheading:7582896-Computer Graphics,
pubmed-meshheading:7582896-Glycine,
pubmed-meshheading:7582896-Hydrogen Bonding,
pubmed-meshheading:7582896-Isomerism,
pubmed-meshheading:7582896-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7582896-Models, Molecular,
pubmed-meshheading:7582896-Models, Structural,
pubmed-meshheading:7582896-Molecular Sequence Data,
pubmed-meshheading:7582896-Peptides,
pubmed-meshheading:7582896-Proline,
pubmed-meshheading:7582896-Protein Conformation,
pubmed-meshheading:7582896-Protein Structure, Secondary,
pubmed-meshheading:7582896-Sea Anemones,
pubmed-meshheading:7582896-Solutions,
pubmed-meshheading:7582896-Structure-Activity Relationship
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pubmed:year |
1995
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pubmed:articleTitle |
Solution structure of the cardiostimulant polypeptide anthopleurin-B and comparison with anthopleurin-A.
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pubmed:affiliation |
NMR Laboratory, Biomolecular Research Institute, Parkville, Australia.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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