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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-12-12
|
| pubmed:abstractText |
Unrelated donor searches for 100 Caucasian patients were referred to France Greffe de Moëlle Registry (FGM) from September 1987 (24,600 donors) to December 1993 (71,500 donors, 61% DR typed). After DR typing of HLA-A,B matched donors, unsuccessful searches were extended to other European Registries for 36 patients. Twenty two patients had a donor (FGM: 19, other Registries: 3) selected on: (1) HLA-A,B and DRB,DQB1 split identity; and (2) unidirectional relative response < 5% in MLR performed twice. Estimated probability of finding a compatible donor at 9 months in FGM was 12% (s.e. +/- 4%) and 25% at 2 years (s.e. +/- 6%). This probability was stringently dependent on a phenoidentity to one very common HLA-A,B,DR or B,DR haplotype (25% at 9 months when present, representing 19 of 19 patients with a compatible donor). Without this phenoidentity, the probability was zero per cent (P = 0.0001) in FGM searches and < 4% (n = 1) in extended searches. The MLR test was shown to be insensitive for screening for DPB1 mismatches. Clinical status influenced the probability of finding a compatible donor at one year ranging from 9% +/- 9% for ALL to 23% +/- 8% for CML (NS). Disregarding DPB1 mismatches is the most efficient way of increasing search efficiency.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
845-51
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7581079-Bone Marrow Transplantation,
pubmed-meshheading:7581079-Europe,
pubmed-meshheading:7581079-European Continental Ancestry Group,
pubmed-meshheading:7581079-France,
pubmed-meshheading:7581079-Gene Frequency,
pubmed-meshheading:7581079-HLA Antigens,
pubmed-meshheading:7581079-HLA-DP Antigens,
pubmed-meshheading:7581079-HLA-DP beta-Chains,
pubmed-meshheading:7581079-Haplotypes,
pubmed-meshheading:7581079-Humans,
pubmed-meshheading:7581079-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:7581079-Registries,
pubmed-meshheading:7581079-Tissue Donors,
pubmed-meshheading:7581079-Tissue and Organ Procurement,
pubmed-meshheading:7581079-Transplantation, Homologous
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Relevance of 10 Caucasian HLA haplotypes in searches for unrelated bone marrow donors for 100 patients from a single center.
|
| pubmed:affiliation |
Histocompatibility Laboratory, Regional Transfusion Center, Rennes, France.
|
| pubmed:publicationType |
Journal Article
|