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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1995-12-12
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pubmed:abstractText |
We investigated the alterations in the coagulation and fibrinolysis systems after aortic aneurysm surgery under cardiopulmonary bypass (CPB) while using newly developed "molecular markers". Fibrinogen and antithrombin III (AT-III) decreased after surgery but returned to normal values within three days. The thrombin-antithrombin III complex (TAT) and plasmin-alpha-2-plasmin inhibitor complex (PIC) both showed increased values even preoperatively, which indicated that coagulation and fibrinolysis were activated in some patients with an aortic aneurysm. Both markers maintained a high level for at least 14 days after surgery. The fibrin degradation product (FDP) also showed an increased value before and after surgery. These results apparently showed that coagulation/fibrinolysis had already been activated in some patients and maintained such a state for at least 14 days after surgery. The relation of activated system and postoperative organ dysfunction as well as the means to suppress such activation are also discussed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0941-1291
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
532-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7579961-Aged,
pubmed-meshheading:7579961-Aneurysm, Dissecting,
pubmed-meshheading:7579961-Antifibrinolytic Agents,
pubmed-meshheading:7579961-Antithrombin III,
pubmed-meshheading:7579961-Aortic Aneurysm, Abdominal,
pubmed-meshheading:7579961-Aortic Aneurysm, Thoracic,
pubmed-meshheading:7579961-Blood Coagulation Tests,
pubmed-meshheading:7579961-Cardiopulmonary Bypass,
pubmed-meshheading:7579961-Disseminated Intravascular Coagulation,
pubmed-meshheading:7579961-Female,
pubmed-meshheading:7579961-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:7579961-Fibrinogen,
pubmed-meshheading:7579961-Fibrinolysin,
pubmed-meshheading:7579961-Fibrinolysis,
pubmed-meshheading:7579961-Humans,
pubmed-meshheading:7579961-Male,
pubmed-meshheading:7579961-Middle Aged,
pubmed-meshheading:7579961-Peptide Hydrolases,
pubmed-meshheading:7579961-Postoperative Complications,
pubmed-meshheading:7579961-Reference Values,
pubmed-meshheading:7579961-Risk Factors,
pubmed-meshheading:7579961-Thrombosis,
pubmed-meshheading:7579961-alpha-2-Antiplasmin,
pubmed-meshheading:7579961-alpha-Macroglobulins
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pubmed:year |
1995
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pubmed:articleTitle |
Alterations in coagulation and fibrinolysis after surgery for aortic aneurysm.
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pubmed:affiliation |
Department of Cardiovascular Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article
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