Linked Life Data

7578884

Source:http://linkedlifedata.com/resource/pubmed/id/7578884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-12-13
pubmed:abstractText
We studied mononuclear cell subsets in 17 patients with primary Sjögren's syndrome (PSS) and in 11 normal controls by flow cytometry. We found a decreased percentage of CD4+ cells (p = 0.027) and a higher percentage of CD8+ cells in patients as compared to controls. In both, CD4+ cells and CD8+ cells, CD25 antigen was overexpressed (p = 0.005 and p = 0.025, respectively as compared to controls). We then measured spontaneous mRNA cytokine expression by T cells from 7 PSS patients and 5 normal controls by coupled reverse transcription-polymerase chain reaction. We found spontaneous mRNA expression for IFN-gamma, IL-10, IL-13 as well as for CD25. Our results suggest an overall T cell activation in PSS patients and provides evidence of a T cell cytokine regulatory imbalance which may play a role in the pathogenesis of this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0891-6934
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Cytokine gene and CD25 antigen expression by peripheral blood T cells from patients with primary Sjögren's syndrome.
pubmed:affiliation
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México, D.F.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't