rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
3
|
pubmed:dateCreated |
1995-11-24
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pubmed:databankReference |
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pubmed:abstractText |
Recent studies have shown that the NADPH oxidase participates in the generation of superoxide anion in non-phagocytic cells. Here we report the isolation and nucleotide sequence of a cDNA for the cytochrome b-558 alpha-subunit of the NADPH oxidase in rat vascular smooth muscle cells (VSMCs). The coding region of the cDNA was 93% homologous to mouse and 81% to human in nucleotide sequence and 96% homologous to mouse and 89% to human in the deduced amino acid sequence. Our results provide a tool with which to explore the mechanism of superoxide anion generation in rat VSMCs and other non-phagocytic cells.
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pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0006-3002
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
1231
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
215-9
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7578211-Amino Acid Sequence,
pubmed-meshheading:7578211-Animals,
pubmed-meshheading:7578211-Aorta,
pubmed-meshheading:7578211-Base Sequence,
pubmed-meshheading:7578211-Cells, Cultured,
pubmed-meshheading:7578211-Cloning, Molecular,
pubmed-meshheading:7578211-Cytochrome b Group,
pubmed-meshheading:7578211-DNA, Complementary,
pubmed-meshheading:7578211-Humans,
pubmed-meshheading:7578211-Male,
pubmed-meshheading:7578211-Mice,
pubmed-meshheading:7578211-Molecular Sequence Data,
pubmed-meshheading:7578211-Muscle, Smooth, Vascular,
pubmed-meshheading:7578211-NADPH Oxidase,
pubmed-meshheading:7578211-Rats,
pubmed-meshheading:7578211-Rats, Sprague-Dawley,
pubmed-meshheading:7578211-Sequence Homology, Amino Acid
|
pubmed:year |
1995
|
pubmed:articleTitle |
Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells.
|
pubmed:affiliation |
Department of Medicine, Emory University, Atlanta, GA 30322, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|