Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1995-12-5
|
| pubmed:abstractText |
An infant cohort treated for skin haemangioma with 226Ra between 1930 and 1965 (n = 11,807) was studied. The median age at treatment was 5-months and 88% were treated before 12 months of age. This cohort was followed up in the Swedish Cancer Registry during the years 1958 to 1989, giving 370,517 person-years at risk. A total number of 248 malignancies have been observed and the standardized incidence ratio (SIR) was 1.21 (confidence interval (CI) 95%, 1.06-1.37). Significantly increased numbers of cancers were found in the central nervous system, 34 cases (SIR = 1.85, CI 95% 1.28-2.59), the thyroid, 15 cases (SIR = 1.88, CI 95% 1.05-3.09) and other endocrine glands, 23 cases (SIR = 2.58, CI 95% 1.64-3.87). The absorbed dose in 11 specified risk organs has been estimated using a phantom of the size of a 5-6-month-old child. The mean absorbed dose in the thyroid was 0.12 Gy and the excess relative risk (ERR) for thyroid cancer was 7.5 per Gy (CI 95% 0.4-18.1). The mean dose in the central nervous system was 0.077 Gy and the ERR for brain tumours was 10.9 per Gy (CI 95% 3.7-20.5). This cohort gives a unique opportunity to analyse long-term effects of low-dose irradiation during infancy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0284-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
735-40
|
| pubmed:dateRevised |
2009-5-12
|
| pubmed:meshHeading |
pubmed-meshheading:7576739-Adolescent,
pubmed-meshheading:7576739-Adult,
pubmed-meshheading:7576739-Brain Neoplasms,
pubmed-meshheading:7576739-Central Nervous System Neoplasms,
pubmed-meshheading:7576739-Child,
pubmed-meshheading:7576739-Cohort Studies,
pubmed-meshheading:7576739-Confidence Intervals,
pubmed-meshheading:7576739-Endocrine Gland Neoplasms,
pubmed-meshheading:7576739-Female,
pubmed-meshheading:7576739-Follow-Up Studies,
pubmed-meshheading:7576739-Hemangioma,
pubmed-meshheading:7576739-Humans,
pubmed-meshheading:7576739-Incidence,
pubmed-meshheading:7576739-Infant,
pubmed-meshheading:7576739-Male,
pubmed-meshheading:7576739-Middle Aged,
pubmed-meshheading:7576739-Neoplasms, Radiation-Induced,
pubmed-meshheading:7576739-Radiotherapy,
pubmed-meshheading:7576739-Radiotherapy Dosage,
pubmed-meshheading:7576739-Radium,
pubmed-meshheading:7576739-Registries,
pubmed-meshheading:7576739-Risk,
pubmed-meshheading:7576739-Skin Neoplasms,
pubmed-meshheading:7576739-Sweden,
pubmed-meshheading:7576739-Thyroid Neoplasms
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Cancer incidence after radiotherapy for skin haemangioma during infancy.
|
| pubmed:affiliation |
Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Göteborg, Sweden.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|