|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1995-12-6
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
We have cloned a receptor, named LSCPR, for vasopressin-related Lys-conopressin in Lymnaea stagnalis. Lys-conopressin evokes Ca(2+)-dependent Cl- currents in Xenopus oocytes injected with LSCPR cRNA. Expression of LSCPR mRNA was detected in central neurons and peripheral muscles associated with reproduction. Upon application of Lys-conopressin, both neurons and muscle cells depolarize owing to an enhancement of voltage-dependent Ca2+ currents and start firing action potentials. Some neurons coexpress LSCPR and Lys-conopressin, suggesting an autotransmitter-like function for this peptide. Lys-conopressin also induces a depolarizing response in LSCPR-expressing neuroendocrine cells that control carbohydrate metabolism. Thus, in addition to oxytocin-like reproductive functions, LSCPR mediates vasopressin-like metabolic functions of Lys-conopressin as well.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Chloride Channels,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxytocin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Oxytocin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasopressins,
http://linkedlifedata.com/resource/pubmed/chemical/conopressin G
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0896-6273
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
897-908
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:7576638-Amino Acid Sequence,
pubmed-meshheading:7576638-Animals,
pubmed-meshheading:7576638-Base Sequence,
pubmed-meshheading:7576638-Calcium,
pubmed-meshheading:7576638-Chloride Channels,
pubmed-meshheading:7576638-Cloning, Molecular,
pubmed-meshheading:7576638-Electric Conductivity,
pubmed-meshheading:7576638-Female,
pubmed-meshheading:7576638-GTP-Binding Proteins,
pubmed-meshheading:7576638-Gene Expression,
pubmed-meshheading:7576638-Gene Transfer Techniques,
pubmed-meshheading:7576638-Lymnaea,
pubmed-meshheading:7576638-Male,
pubmed-meshheading:7576638-Membrane Proteins,
pubmed-meshheading:7576638-Molecular Sequence Data,
pubmed-meshheading:7576638-Oocytes,
pubmed-meshheading:7576638-Organ Specificity,
pubmed-meshheading:7576638-Oxytocin,
pubmed-meshheading:7576638-RNA, Messenger,
pubmed-meshheading:7576638-Receptors, Oxytocin,
pubmed-meshheading:7576638-Receptors, Vasopressin,
pubmed-meshheading:7576638-Sequence Alignment,
pubmed-meshheading:7576638-Vasopressins,
pubmed-meshheading:7576638-Xenopus
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
A novel G protein-coupled receptor mediating both vasopressin- and oxytocin-like functions of Lys-conopressin in Lymnaea stagnalis.
|
|
pubmed:affiliation |
Department of Experimental Zoology, Graduate School of Neurosciences Amsterdam, Institute of Neuroscience, Vrije Universiteit, Amsterdam, The Netherlands.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
