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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1995-11-9
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pubmed:abstractText |
Aprotinin causes a prolongation of the celite-activated clotting time (CACT), but not of the kaolin-activated clotting time (KACT). Therefore, concern has been raised regarding the reliability of CACT to monitor anticoagulation in the presence of aprotinin. The current study was designed to test the efficacy of aprotinin to improve anticoagulation, and to investigate whether the prolongation of CACT reflects true anticoagulation or is an in vitro artifact. To elucidate this antithrombotic effect of aprotinin, this study was done in patients prone to reduced intraoperative heparin sensitivity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0003-3022
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
679-89; discussion 29A-30A
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7574046-Adult,
pubmed-meshheading:7574046-Aged,
pubmed-meshheading:7574046-Aprotinin,
pubmed-meshheading:7574046-Blood Coagulation,
pubmed-meshheading:7574046-Blood Transfusion,
pubmed-meshheading:7574046-Coronary Artery Bypass,
pubmed-meshheading:7574046-Diatomaceous Earth,
pubmed-meshheading:7574046-Double-Blind Method,
pubmed-meshheading:7574046-Heparin,
pubmed-meshheading:7574046-Humans,
pubmed-meshheading:7574046-Kaolin,
pubmed-meshheading:7574046-Male,
pubmed-meshheading:7574046-Middle Aged,
pubmed-meshheading:7574046-Prospective Studies,
pubmed-meshheading:7574046-Serine Proteinase Inhibitors,
pubmed-meshheading:7574046-Thrombin
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pubmed:year |
1995
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pubmed:articleTitle |
Influence of high-dose aprotinin on anticoagulation, heparin requirement, and celite- and kaolin-activated clotting time in heparin-pretreated patients undergoing open-heart surgery. A double-blind, placebo-controlled study.
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pubmed:affiliation |
Department of Anesthesiology, German Heart Center, Munich, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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