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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5232
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pubmed:dateCreated |
1995-11-6
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pubmed:abstractText |
The baculovirus antiapoptotic protein p35 inhibited the proteolytic activity of human interleukin-1 beta converting enzyme (ICE) and three of its homologs in enzymatic assays. Coexpression of p35 prevented the autoproteolytic activation of ICE from its precursor form and blocked ICE-induced apoptosis. Inhibition of enzymatic activity correlated with the cleavage of p35 and the formation of a stable ICE-p35 complex. The ability of p35 to block apoptosis in different pathways and in distantly related organisms suggests a central and conserved role for ICE-like proteases in the induction of apoptosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
1885-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7569933-Amino Acid Sequence,
pubmed-meshheading:7569933-Animals,
pubmed-meshheading:7569933-Apoptosis,
pubmed-meshheading:7569933-Binding, Competitive,
pubmed-meshheading:7569933-Binding Sites,
pubmed-meshheading:7569933-Caspase 1,
pubmed-meshheading:7569933-Cell Line,
pubmed-meshheading:7569933-Cysteine Endopeptidases,
pubmed-meshheading:7569933-Cysteine Proteinase Inhibitors,
pubmed-meshheading:7569933-Enzyme Activation,
pubmed-meshheading:7569933-Humans,
pubmed-meshheading:7569933-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:7569933-Molecular Sequence Data,
pubmed-meshheading:7569933-Recombinant Proteins,
pubmed-meshheading:7569933-Transfection,
pubmed-meshheading:7569933-Viral Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.
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pubmed:affiliation |
BASF Bioresearch Corporation, Worcester, MA 01605, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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