Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
21
pubmed:dateCreated
1995-11-14
pubmed:abstractText
Kindling, an animal model of epilepsy wherein seizures are induced by subcortical electrical stimulation, results in the upregulation of neurotrophin mRNA and protein in the adult rat forebrain and causes mossy fiber sprouting in the hippocampus. Intraventricular infusion of a synthetic peptide mimic of a nerve growth factor domain that interferes with the binding of neurotrophins to their receptors resulted in significant retardation of kindling and inhibition of mossy fiber sprouting. These findings suggest a critical role for neurotrophins in both kindling and kindling-induced synaptic reorganization.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1313952, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1327010, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1334664, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1479072, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1486956, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1488112, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1525666, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1653651, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1688328, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1829904, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-1846041, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2065656, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2084116, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2100197, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2156542, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2158007, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2160854, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2164684, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2206535, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2449733, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2508534, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2542847, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2542848, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-2549634, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-3208092, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-3841294, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-4018405, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-4110397, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-4981856, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-6785259, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-7517456, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-7531892, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-7623154, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-7890832, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-8182460, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-8226840, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-8339771, http://linkedlifedata.com/resource/pubmed/commentcorrection/7568161-8439408
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9495-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:7568161-Animals, pubmed-meshheading:7568161-Biological Assay, pubmed-meshheading:7568161-Brain-Derived Neurotrophic Factor, pubmed-meshheading:7568161-Electric Stimulation, pubmed-meshheading:7568161-Epilepsy, pubmed-meshheading:7568161-Ganglia, pubmed-meshheading:7568161-Ganglia, Spinal, pubmed-meshheading:7568161-Hippocampus, pubmed-meshheading:7568161-Histocytochemistry, pubmed-meshheading:7568161-Kindling, Neurologic, pubmed-meshheading:7568161-Male, pubmed-meshheading:7568161-Nerve Fibers, pubmed-meshheading:7568161-Nerve Growth Factors, pubmed-meshheading:7568161-Nerve Tissue Proteins, pubmed-meshheading:7568161-Neurotrophin 3, pubmed-meshheading:7568161-Peptide Fragments, pubmed-meshheading:7568161-Rats, pubmed-meshheading:7568161-Receptors, Nerve Growth Factor, pubmed-meshheading:7568161-Seizures, pubmed-meshheading:7568161-Superior Cervical Ganglion
pubmed:year
1995
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