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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
1995-11-14
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pubmed:abstractText |
The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease, suggesting that apoE may directly influence neurons in the aging brain. Recent data suggest that apoE-containing lipoproteins can influence neurite outgrowth in an isoform-specific fashion. The neuronal mediators of apoE effects have not been clarified. We show here that in a central nervous system-derived neuronal cell line, apoE3 but not apoE4 increases neurite extension. The effect of apoE3 was blocked at low nanomolar concentrations by purified 39-kDa protein that regulates ligand binding to the low density lipoprotein receptor-related protein (LRP). Anti-LRP antibody also completely abolished the neurite-promoting effect of apoE3. Understanding isoform-specific cell biological processes mediated by apoE-LRP interactions in central nervous system neurons may provide insight into Alzheimer disease pathogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1322401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1423505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1464751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1632469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1698775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1718973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-1789684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-2029618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-2196069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-2355022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-2762297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-291993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3115992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3266596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3513163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3513311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3539206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3576212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3791064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-3932467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-7518435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-7678262,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-7920638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-7944146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-7979249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8136829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8159279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8170995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8171342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8280086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8346443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8350998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8389767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8398148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7568158-8446617
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,3'-dioctadecylindocarbocyanine,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein E3,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Carbocyanines,
http://linkedlifedata.com/resource/pubmed/chemical/Cross-Linking Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9480-4
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7568158-Apolipoprotein E3,
pubmed-meshheading:7568158-Apolipoproteins E,
pubmed-meshheading:7568158-Carbocyanines,
pubmed-meshheading:7568158-Cell Line,
pubmed-meshheading:7568158-Cross-Linking Reagents,
pubmed-meshheading:7568158-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:7568158-Fluorescent Dyes,
pubmed-meshheading:7568158-Hypothalamus,
pubmed-meshheading:7568158-Low Density Lipoprotein Receptor-Related Protein-1,
pubmed-meshheading:7568158-Microscopy, Confocal,
pubmed-meshheading:7568158-Microscopy, Fluorescence,
pubmed-meshheading:7568158-Neurites,
pubmed-meshheading:7568158-Neurons,
pubmed-meshheading:7568158-Receptors, Immunologic,
pubmed-meshheading:7568158-Receptors, LDL,
pubmed-meshheading:7568158-Recombinant Proteins
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pubmed:year |
1995
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pubmed:articleTitle |
Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.
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pubmed:affiliation |
Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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