7567474

Source:http://linkedlifedata.com/resource/pubmed/id/7567474

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0028953, umls-concept:C0029016, umls-concept:C0086661, umls-concept:C0185117, umls-concept:C0205431, umls-concept:C0301625, umls-concept:C1512505, umls-concept:C2911684
pubmed:issue	17
pubmed:dateCreated	1995-11-6
pubmed:abstractText	Polyamines are excellent stabilizers of triplex DNA. Recent studies in our laboratory revealed a remarkable structural specificity of polyamines in the induction and stabilization of triplex DNA. 1,3-Diaminopropane (DAP) showed optimum efficacy amongst a series of synthetic diamines in stabilizing triplex DNA. To utilize the potential of this finding in developing an anti-gene strategy for breast cancer, we treated MCF-7 cells with a 37mer oligonucleotide to form triplex DNA in the up-stream regulatory region of the c-myc oncogene in the presence of DAP. As individual agents, the oligonucleotide and DAP did not downregulate c-myc mRNA in the presence of estradiol. Complexation of the oligonucleotide with 2 mM DAP reduced c-myc mRNA signal by 65% at 10 microM oligonucleotide concentration. In contrast, a control oligonucleotide had no significant effect on c-myc mRNA. The expression of c-fos oncogene was not significantly altered by the triplex forming oligonucleotide (TFO). DAP was internalized within 1 h of treatment; however, it had no significant effect on the level of natural polyamines. These data indicate that selective utilization of synthetic polyamines and TFOs might be an important strategy to develop anti-gene-based therapeutic modalities for breast cancer.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA 42439
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0411011
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides, http://linkedlifedata.com/resource/pubmed/chemical/Polyamines, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	0305-1048
pubmed:author	pubmed-author:FaalandC ACA, pubmed-author:GalliM GMG, pubmed-author:ThomasT JTJ, pubmed-author:ThomasTT
pubmed:issnType	Print
pubmed:day	11
pubmed:volume	23
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3594-9
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:7567474-Antineoplastic Agents, pubmed-meshheading:7567474-Base Sequence, pubmed-meshheading:7567474-Breast Neoplasms, pubmed-meshheading:7567474-Female, pubmed-meshheading:7567474-Gene Expression Regulation, Neoplastic, pubmed-meshheading:7567474-Genes, myc, pubmed-meshheading:7567474-Humans, pubmed-meshheading:7567474-Molecular Sequence Data, pubmed-meshheading:7567474-Nucleic Acid Hybridization, pubmed-meshheading:7567474-Oligodeoxyribonucleotides, pubmed-meshheading:7567474-Polyamines, pubmed-meshheading:7567474-RNA, Messenger, pubmed-meshheading:7567474-RNA, Neoplasm, pubmed-meshheading:7567474-Tumor Cells, Cultured
pubmed:year	1995
pubmed:articleTitle	Suppression of c-myc oncogene expression by a polyamine-complexed triplex forming oligonucleotide in MCF-7 breast cancer cells.
pubmed:affiliation	Program in Clinical Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick 08903, USA.
pubmed:publicationType	Journal Article, In Vitro

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