| pubmed-article:7566703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C1517324 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C0032744 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C1519355 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C0260193 | lld:lifeskim |
| pubmed-article:7566703 | lifeskim:mentions | umls-concept:C0233929 | lld:lifeskim |
| pubmed-article:7566703 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7566703 | pubmed:dateCreated | 1995-10-26 | lld:pubmed |
| pubmed-article:7566703 | pubmed:abstractText | Positron-emitting radionuclides have short half-lives and high radiation energies compared with radioisotopes generally used in biomedical research. We examined the possibility of applying positron emitter-labeled compounds to functional imaging in brain slices kept viable in an oxygenated buffer solution. Brain slices (300 microns thick) containing the striatum were incubated with positron emitter-labeled tracers for 30-45 min. The slices were then rinsed and placed on the bottom of a Plexiglas chamber filled with oxygenated Krebs-Ringer solution. The bottom of the chamber consisted of a thin polypropylene film to allow good penetration of beta+ particles from the brain slices. The chamber was placed on a storage phosphor screen, which has a higher sensitivity and a wider dynamic range than X-ray films. After an exposure period of 15-60 min, the screen was scanned by the analyzer and radioactivity images of brain slices were obtained within 20 min. We succeeded in obtaining quantitative images of (1) [18F]fluorodeoxyglucose uptake, (2) dopamine D2 receptor binding, (3) dopa-decarboxylase activity, and (4) release of [11C]dopamine preloaded as L-[11C]DOPA in the brain slice preparation. These results demonstrate that positron emitter-labeled tracers in combination with storage phosphor screens are useful for functional imaging of living brain slices as a novel neuroscience technique. | lld:pubmed |
| pubmed-article:7566703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7566703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7566703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7566703 | pubmed:month | May | lld:pubmed |
| pubmed-article:7566703 | pubmed:issn | 0168-0102 | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:WatanabeYY | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:AntoniGG | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:MatsumuraKK | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:BergströmMM | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:TakechiHH | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:LångströmBB | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:BjurlingPP | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:OnoeHH | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:WesterbergGG | lld:pubmed |
| pubmed-article:7566703 | pubmed:author | pubmed-author:JacobsonG BGB | lld:pubmed |
| pubmed-article:7566703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7566703 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:7566703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7566703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7566703 | pubmed:pagination | 219-29 | lld:pubmed |
| pubmed-article:7566703 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:7566703 | pubmed:meshHeading | pubmed-meshheading:7566703-... | lld:pubmed |
| pubmed-article:7566703 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7566703 | pubmed:articleTitle | In vitro positron emission tomography (PET): use of positron emission tracers in functional imaging in living brain slices. | lld:pubmed |
| pubmed-article:7566703 | pubmed:affiliation | Subfemtomole Biorecognition Project, Research Development Corporation of Japan, Osaka. | lld:pubmed |
| pubmed-article:7566703 | pubmed:publicationType | Journal Article | lld:pubmed |
