Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1995-10-24
pubmed:abstractText
Incorporation of myo-[2-3H]-inositol into peripheral blood mononuclear cells (PBMNC) and T-cell enriched lymphocytes was evaluated in in-vitro experiments in chronic renal failure (CRF) patients and healthy subjects. Incorporation of myo-[2-3H]-inositol into the cells of CRF patients on conservative and haemodialysis treatment was found to be impaired in comparison with that observed in normal cells. Following PHA stimulation of the cells of CRF patients myo-[2-3H]-inositol incorporation decreased even further, while it increased in normal cells. Five-hour haemodialysis session significantly depressed myoinositol incorporation into PBMNC, while its incorporation into T-cell enriched lymphocytes remained unaffected. Myoinositol incorporation into PBMNC and T-cell enriched lymphocytes was inhibited by prostaglandins and leukotrienes and was inversely related to the extent of pertussis toxinsensitive G protein activation. Reduced myoinositol incorporation into uraemic PHA-stimulated PBMNC may depend at least in part on their enhanced PGE2 and LTB4 release accompanied by increased intracellular cAMP production. In CRF impaired myoinositol incorporation into immune cells may prove the disarrangement in the early events of transmembrane signal transduction, which may share the responsibility for the cell-mediated immune defect in these patients.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0931-0509
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
637-42
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed-meshheading:7566575-Adult, pubmed-meshheading:7566575-Aluminum, pubmed-meshheading:7566575-Cell Membrane, pubmed-meshheading:7566575-Cells, Cultured, pubmed-meshheading:7566575-Cyclic AMP, pubmed-meshheading:7566575-Cyclooxygenase Inhibitors, pubmed-meshheading:7566575-Dinoprostone, pubmed-meshheading:7566575-Female, pubmed-meshheading:7566575-Fluorine, pubmed-meshheading:7566575-Humans, pubmed-meshheading:7566575-Inositol, pubmed-meshheading:7566575-Intracellular Fluid, pubmed-meshheading:7566575-Kidney Failure, Chronic, pubmed-meshheading:7566575-Leukotriene B4, pubmed-meshheading:7566575-Lipoxygenase Inhibitors, pubmed-meshheading:7566575-Male, pubmed-meshheading:7566575-Monocytes, pubmed-meshheading:7566575-Phytohemagglutinins, pubmed-meshheading:7566575-Renal Dialysis, pubmed-meshheading:7566575-T-Lymphocytes
pubmed:year
1995
pubmed:articleTitle
Myoinositol incorporation into lymphocytes of chronic renal failure patients is impaired.
pubmed:affiliation
2nd Department of Internal Medicine, WAM, Lód?, Poland.
pubmed:publicationType
Journal Article