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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6550
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pubmed:dateCreated |
1995-11-14
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pubmed:abstractText |
The Ets-1 proto-oncogene is a member of the Ets family of eukaryotic transcription factors. Members of this family play important roles in regulating gene expression in response to multiple developmental and mitogenic signals. Ets-1 is preferentially expressed at high levels in B and T cells of adult mice and is regulated during both thymocyte development and T-cell activation. To study the role of Ets-1 in T-cell development and function we have used the RAG-2-/- complementation system and murine embryonic stem (ES) cells containing homozygous deletions in the Ets-1 gene (Ets-1-/-). Ets-1-/(-)-RAG-2-/- chimaeric mice displayed markedly decreased numbers of mature thymocytes and peripheral T cells. Ets-1-/- T cells expressed normal levels of CD3 and T-cell antigen receptor (TCR)-alpha/beta. However, they displayed a severe proliferative defect in response to multiple activational signals and demonstrated increased rates of spontaneous apoptosis in vitro. These findings demonstrate that Ets-1 is required for the normal survival and activation of murine T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD3,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ETS1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Ets1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Protein c-ets-1,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-ets,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
377
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
639-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7566177-Animals,
pubmed-meshheading:7566177-Antigens, CD3,
pubmed-meshheading:7566177-Antigens, CD4,
pubmed-meshheading:7566177-Antigens, CD8,
pubmed-meshheading:7566177-Apoptosis,
pubmed-meshheading:7566177-Cell Division,
pubmed-meshheading:7566177-Cell Line,
pubmed-meshheading:7566177-Cell Survival,
pubmed-meshheading:7566177-Chimera,
pubmed-meshheading:7566177-DNA-Binding Proteins,
pubmed-meshheading:7566177-Lymphocyte Activation,
pubmed-meshheading:7566177-Mice,
pubmed-meshheading:7566177-Proteins,
pubmed-meshheading:7566177-Proto-Oncogene Protein c-ets-1,
pubmed-meshheading:7566177-Proto-Oncogene Proteins,
pubmed-meshheading:7566177-Proto-Oncogene Proteins c-ets,
pubmed-meshheading:7566177-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7566177-Sequence Deletion,
pubmed-meshheading:7566177-Spleen,
pubmed-meshheading:7566177-Stem Cells,
pubmed-meshheading:7566177-T-Lymphocytes,
pubmed-meshheading:7566177-Transcription Factors
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pubmed:year |
1995
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pubmed:articleTitle |
Defective activation and survival of T cells lacking the Ets-1 transcription factor.
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pubmed:affiliation |
Department of Medicine, University of Chicago, Illinois 60637, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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