|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6548
|
|
pubmed:dateCreated |
1995-11-8
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
Thyroid-hormone and retinoic-acid receptors exert their regulatory functions by acting as both activators and repressors of gene expression. A nuclear receptor co-repressor (N-CoR) of relative molecular mass 270K has been identified which mediates ligand-independent inhibition of gene transcription by these receptors, suggesting that the molecular mechanisms of repression by thyroid-hormone and retinoic-acid receptors are analogous to the co-repressor-dependent transcriptional inhibitory mechanisms of yeast and Drosophila.
|
|
pubmed:commentsCorrections |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 1,
http://linkedlifedata.com/resource/pubmed/chemical/Oligodeoxyribonucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Retinoic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Thyroid Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tretinoin,
http://linkedlifedata.com/resource/pubmed/chemical/Triiodothyronine,
http://linkedlifedata.com/resource/pubmed/chemical/retinoic acid receptor beta
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0028-0836
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
377
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
N
|
|
pubmed:pagination |
397-404
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7566114-Amino Acid Sequence,
pubmed-meshheading:7566114-Animals,
pubmed-meshheading:7566114-Base Sequence,
pubmed-meshheading:7566114-Binding Sites,
pubmed-meshheading:7566114-Cell Line,
pubmed-meshheading:7566114-DNA,
pubmed-meshheading:7566114-Gene Expression Regulation,
pubmed-meshheading:7566114-Humans,
pubmed-meshheading:7566114-Ligands,
pubmed-meshheading:7566114-Mice,
pubmed-meshheading:7566114-Molecular Sequence Data,
pubmed-meshheading:7566114-Mutagenesis, Site-Directed,
pubmed-meshheading:7566114-Nuclear Proteins,
pubmed-meshheading:7566114-Nuclear Receptor Co-Repressor 1,
pubmed-meshheading:7566114-Oligodeoxyribonucleotides,
pubmed-meshheading:7566114-Protein Binding,
pubmed-meshheading:7566114-Receptors, Retinoic Acid,
pubmed-meshheading:7566114-Receptors, Thyroid Hormone,
pubmed-meshheading:7566114-Recombinant Fusion Proteins,
pubmed-meshheading:7566114-Repressor Proteins,
pubmed-meshheading:7566114-Transcription, Genetic,
pubmed-meshheading:7566114-Transfection,
pubmed-meshheading:7566114-Tretinoin,
pubmed-meshheading:7566114-Triiodothyronine
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor.
|
|
pubmed:affiliation |
Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093-0648, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|
