Linked Life Data

7565496

Source:http://linkedlifedata.com/resource/pubmed/id/7565496

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1995-11-22
pubmed:abstractText
An immunostaining technique using monoclonal antibodies to a neurofilament protein has allowed us to visualize defects in the development of cranial nerves and ganglia of 10 to 10.5 days mouse embryos following exposure to ethanol in whole embryo culture. Reference patterns for development of cranial nerves and ganglia of control mouse embryos explanted and examined when they had 25 to 34 pairs of somites were established. Additionally, control mouse embryos were grown in whole embryo culture for 48 h, with culture being initiated in embryos having 6 to 7 somite pairs. At the end of the culture period, only minor differences were observed between the control groups. An experimental group of embryos was cultured in the presence of increasing doses (1.6, 3.2, 4, and 4.8 g/l) of ethanol. Defects were observed in the development of the glossopharyngeal and vagus nerves. These abnormalities included absence of the dorsal root (superior ganglion) of IX, star-like shape of inferior ganglion IX, disorganization of the rootlets of nerve X and abnormal fibers between the two nerves and ganglia. These results suggest that the migration and patterning of neural crest cells derived from r6 and r7 may be particularly affected by ethanol. The results also demonstrate the usefulness of this approach in evaluating the susceptibility of the developing cranial nerves to toxicant exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0892-0362
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
497-506
pubmed:dateRevised
2009-10-26
pubmed:meshHeading
pubmed:articleTitle
Alterations of mouse embryonic branchial nerves and ganglia induced by ethanol.
pubmed:affiliation
Laboratory of Developmental Genetics, Catholic University of Louvain, Louvain-la-Neuve, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't