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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-11-7
|
| pubmed:abstractText |
One of the physiological roles of glutamine is as a precursor for DNA synthesis. The aims of this study were to determine (1) whether glutamine-supplemented total parenteral nutrition (TPN) enhanced DNA and protein synthesis in the liver and (2) whether glutamine uptake was increased following partial hepatectomy in rats. Male Donryu rats (n = 59; body weight, 250-275 g) were randomized into four groups: (1) sham operation + standard TPN solution (C-STPN); (2) C + glutamine-supplemented TPN (C-GTPN); (3) 70% partial hepatectomy + STPN (H-STPN); (4) partial hepatectomy + GTPN (H-GTPN). On Day 0, rats underwent either a sham operation or 70% partial hepatectomy and concomitantly were catheterized in the jugular vein. TPN was begun immediately after the surgery. GTPN was isocaloric and isonitrogenous with STPN and 25% of total nitrogen was given as glutamine. On Day 2, the animals were sacrificed after either a continuous infusion of 1-14C-leucine or a bolus i.v. injection of bromodeoxyuridine. The rate of hepatic regeneration was enhanced with glutamine supplementation (H-STPN, 60.8 +/- 1.6% vs H-GTPN, 66.3 +/- 2.0, P < 0.05) due to an increase in protein synthesis in the liver (H-STPN, 134.0 +/- 10.3%/day vs H-GTPN, 160.9 +/- 6.9, P < 0.05) and DNA synthesis in hepatocytes (H-STPN, 23.1 +/- 2.5% vs H-GTPN, 31.4 +/- 2.9, P < 0.05). The uptake of glutamine by the liver was increased following hepatectomy with GTPN supplementation.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
59
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
475-81
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7564320-Animals,
pubmed-meshheading:7564320-Body Weight,
pubmed-meshheading:7564320-Bromodeoxyuridine,
pubmed-meshheading:7564320-Cell Division,
pubmed-meshheading:7564320-DNA,
pubmed-meshheading:7564320-Glutamine,
pubmed-meshheading:7564320-Hepatectomy,
pubmed-meshheading:7564320-Intestinal Mucosa,
pubmed-meshheading:7564320-Liver,
pubmed-meshheading:7564320-Liver Regeneration,
pubmed-meshheading:7564320-Male,
pubmed-meshheading:7564320-Protein Biosynthesis,
pubmed-meshheading:7564320-Rats
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Effect of glutamine supplement and hepatectomy on DNA and protein synthesis in the remnant liver.
|
| pubmed:affiliation |
First Department of Surgery, Kurume University, School of Medicine, Fukuoka, Japan.
|
| pubmed:publicationType |
Journal Article
|