Linked Life Data

7564279

Source:http://linkedlifedata.com/resource/pubmed/id/7564279

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-10-20
pubmed:abstractText
We have shown that the nicotine-derived nitrosamine 4-(methyl-nitrosamino)-3-(pyridyl)-1-butanone (NNK) causes a high incidence of neuroendocrine lung tumors in male Syrian golden hamsters when administered to animals maintained in an atmosphere of 60% hyperoxia. In vitro studies with fetal hamster pulmonary neuroendocrine cells (PNE cells) and human neuroendocrine lung cancer cell lines revealed that nicotine and NNK are both potent mitogens for normal and neoplastic PNE cells when the cells were maintained in an atmosphere of high CO2. These effects were completely inhibited by antagonists of nicotinic acetylcholine receptors (nAChR). NNK displaced 3H-(-)L-nicotine from the nAchR in radioreceptor assays with cell membrane fractions from hamster lungs enriched in PNE cells. We therefore hypothesized that NNK acts as an agonist of the nAchR in PNE cells and that stimulation of this receptor in an environment of impaired pulmonary oxygenation is an important molecular event leading to the development of lung tumors with a neuroendocrine phenotype.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
448-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Simultaneous exposure to nicotine and hyperoxia causes tumors in hamsters.
pubmed:affiliation
Carcinogenesis and Developmental Therapeutics Program, College of Veterinary Medicine, University of Tennessee, Knoxville, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.