Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-11-20
|
| pubmed:abstractText |
In a retrospective study the expression of the resistance proteins P-170 glycoprotein (P-170), glutathione S-transferase pi (GST-pi), thymidylate-synthase (TS), dihydrofolate reductase (DHFR) and metallothionein (MT) was investigated in 111 patients with newly diagnosed acute lymphoblastic leukemia (ALL) using the streptavidin-biotin-peroxidase complex method. The expression of the resistance proteins was found in following frequency: P-170 in 39 (35%), GST-pi in 54 (49%), TS in 46 (42%), DHFR in 21 (20%) and MT in 30 (33%) cases of the investigated patients. Patients with overexpression of P-170 or GST-pi had a significant lower probability of remaining in continuous first remission (P < 0.05 for P-170 and P < 0.01 for GST-pi). The expression of TS and DHFR had no prognostic significance on the probability of first remission. Patients with MT-overexpression showed only a tendency for a lower probability of continuous first remission. Coexpression of P-170 and GST-pi was observed in leukemias of 22 patients (21%) and 38 patients (37%) showed no evidence for the expression of both markers. Combining P-170 and GST-pi improved the prognostic value. The expression of the resistance proteins was independent of age, sex, FAB-type, immunological subtype and of the initial peripheral blast cell count. The multivariate analysis indicated that only the expression of P-170 was an independent unfavorable prognostic factor for children with initial ALL. The reason for this was an minor correlation of P-170 and GST-pi (P = 0.01).
|
| pubmed:language |
ger
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Metallothionein,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydrofolate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidylate Synthase
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8630
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
207
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
230-4
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7564159-Adolescent,
pubmed-meshheading:7564159-Child,
pubmed-meshheading:7564159-Child, Preschool,
pubmed-meshheading:7564159-Drug Resistance, Neoplasm,
pubmed-meshheading:7564159-Female,
pubmed-meshheading:7564159-Gene Expression Regulation, Leukemic,
pubmed-meshheading:7564159-Glutathione Transferase,
pubmed-meshheading:7564159-Humans,
pubmed-meshheading:7564159-Infant,
pubmed-meshheading:7564159-Male,
pubmed-meshheading:7564159-Metallothionein,
pubmed-meshheading:7564159-P-Glycoprotein,
pubmed-meshheading:7564159-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:7564159-Prognosis,
pubmed-meshheading:7564159-Remission Induction,
pubmed-meshheading:7564159-Retrospective Studies,
pubmed-meshheading:7564159-Tetrahydrofolate Dehydrogenase,
pubmed-meshheading:7564159-Thymidylate Synthase
|
| pubmed:articleTitle |
[Expression and clinical significance of resistance proteins in initial acute lymphatic leukemia (ALL) in childhood].
|
| pubmed:affiliation |
Klinikum der Friedrich-Schiller-Universität Jena.
|
| pubmed:publicationType |
Journal Article,
English Abstract
|