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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1978-4-17
|
| pubmed:abstractText |
Early epidermal changes in human subjects following application of 10% croton oil in acetone were studied by electron microscopy. The prominent changes observed at 1 and 5 hours were degeneration of epidermal cells and intercellular edema in the basal and spinous layers. One type of degeneration was homogenization and aggregation of the tonofilaments of keratinocytes at 1 hour, which may explain the presence of dyskeratotic cells at 5 hours. Another type was of a cytolytic nature as evidenced by severe perinuclear edema of keratinocytes and destruction of Langerhans' cells with outpouring of Birbeck's granules in the intercellular spaces.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0001-5555
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
58
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
31-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:75633-Cell Membrane,
pubmed-meshheading:75633-Croton Oil,
pubmed-meshheading:75633-Cytoplasm,
pubmed-meshheading:75633-Dermatitis, Contact,
pubmed-meshheading:75633-Epidermis,
pubmed-meshheading:75633-Humans,
pubmed-meshheading:75633-Microscopy, Electron,
pubmed-meshheading:75633-Time Factors
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Early fine structural changes in human epidermis following application of croton oil.
|
| pubmed:publicationType |
Journal Article
|