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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
1995-10-30
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pubmed:abstractText |
Matrix metalloproteinases (MMPs) are involved in the invasion and metastasis of human cancers by mediating the degradation of extracellular matrix components. Therefore, these enzymes constitute promising targets in the development of anticancer therapies. Batimastat ([(4-N-hydroxyamino)-2R-isobutyl-3S-(thienyl-thiomethyl)succinyl]-L- phenyl-alanine-N-methylamide) is one of a new class of agents designed to inhibit MMP activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1546-50
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7563189-Animals,
pubmed-meshheading:7563189-Breast Neoplasms,
pubmed-meshheading:7563189-Chemotherapy, Adjuvant,
pubmed-meshheading:7563189-Chi-Square Distribution,
pubmed-meshheading:7563189-Collagenases,
pubmed-meshheading:7563189-Female,
pubmed-meshheading:7563189-Humans,
pubmed-meshheading:7563189-Linear Models,
pubmed-meshheading:7563189-Lung Neoplasms,
pubmed-meshheading:7563189-Metalloendopeptidases,
pubmed-meshheading:7563189-Mice,
pubmed-meshheading:7563189-Mice, Nude,
pubmed-meshheading:7563189-Neoplasm Recurrence, Local,
pubmed-meshheading:7563189-Neoplasm Transplantation,
pubmed-meshheading:7563189-Phenylalanine,
pubmed-meshheading:7563189-RNA, Messenger,
pubmed-meshheading:7563189-RNA, Neoplasm,
pubmed-meshheading:7563189-Thiophenes,
pubmed-meshheading:7563189-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
Effect of matrix metalloproteinase inhibitor batimastat on breast cancer regrowth and metastasis in athymic mice.
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pubmed:affiliation |
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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