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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
1995-10-26
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pubmed:abstractText |
Development of uterine cervical cancer is preceded by preneoplastic proliferative changes in the cervical epithelium called "intra-epithelial neoplasia" or "dysplasia." The genetic basis of the origin and progression of such preneoplastic lesions is not known. By analysis of carcinomas for loss of constitutional heterozygosity (LOH), we have previously shown a high frequency of allelic loss in the short arm of chromosome 5 (5p), suggesting loss of a candidate tumor suppressor gene located in 5p and associated with the development of this tumor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
17
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
742-5
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7563151-Chromosome Deletion,
pubmed-meshheading:7563151-Chromosomes, Human, Pair 5,
pubmed-meshheading:7563151-DNA, Neoplasm,
pubmed-meshheading:7563151-DNA, Satellite,
pubmed-meshheading:7563151-Female,
pubmed-meshheading:7563151-Genetic Markers,
pubmed-meshheading:7563151-Heterozygote,
pubmed-meshheading:7563151-Humans,
pubmed-meshheading:7563151-Oligodeoxyribonucleotides,
pubmed-meshheading:7563151-Polymorphism, Genetic,
pubmed-meshheading:7563151-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:7563151-Tumor Markers, Biological,
pubmed-meshheading:7563151-Uterine Cervical Dysplasia,
pubmed-meshheading:7563151-Uterine Cervical Neoplasms
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pubmed:year |
1995
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pubmed:articleTitle |
Genetic alterations at 5p15: a potential marker for progression of precancerous lesions of the uterine cervix.
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pubmed:affiliation |
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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