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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1995-11-22
|
| pubmed:abstractText |
Serum levels of procollagen type I carboxy-terminal extension peptide (PICP) reflect the synthesis of type I collagen. As PICP is produced by osteoblasts and is not incorporated into bone matrix, serum PICP levels have been suggested as a marker of bone formation. In 37 cancer patients (21 men and 16 women; age: 72.4 +/- 8.6 (mean +/- SD) years) with bone metastases and 23 women (age: 77.3 +/- 6.64 years) as controls, the following biochemical variables were measured: serum PICP, calcium (Ca), phosphorus, alkaline phosphatase (AP) and tartrate-resistant acid phosphatase (TRAP), and urinary hydroxyproline and calcium corrected for creatinine excretion. Higher serum levels of PICP were observed in cancer patients than in control (245 +/- 177 micrograms/l vs 121.7 +/- 36 micrograms/l, p < 0.01). Cancer patients also had higher AP levels than controls (704 +/- 755 U/l vs 216.5 +/- 56 U/l, p < 0.01). Abnormal PICP and AP serum concentrations (above the mean + 2SD of controls) were found in 46% and 51% of patients, respectively. Moreover, patients showed significantly lower serum calcium concentrations (p < 0.001), and higher TRAP and hydroxyproline levels although statistical significance was not reached. In the patients, PICP was correlated directly with AP (r = 0.50, p < 0.01) and TRAP (r = 0.34, p < 0.05). In conclusion, patients with bone metastases have increased bone turnover as shown by serum markers. Serum PICP may be used as an adjunctive, non-invasive index to assess bone metabolism. However, the clinical usefulness of PICP in cancer patients needs further evaluations.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxyproline,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorus,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/procollagen type I carboxy...,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0393-6155
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
107-12
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:7561234-Acid Phosphatase,
pubmed-meshheading:7561234-Aged,
pubmed-meshheading:7561234-Alkaline Phosphatase,
pubmed-meshheading:7561234-Bone Diseases, Metabolic,
pubmed-meshheading:7561234-Bone Neoplasms,
pubmed-meshheading:7561234-Bone Resorption,
pubmed-meshheading:7561234-Bone and Bones,
pubmed-meshheading:7561234-Calcium,
pubmed-meshheading:7561234-Female,
pubmed-meshheading:7561234-Humans,
pubmed-meshheading:7561234-Hydroxyproline,
pubmed-meshheading:7561234-Isoenzymes,
pubmed-meshheading:7561234-Male,
pubmed-meshheading:7561234-Neoplasm Proteins,
pubmed-meshheading:7561234-Osteoblasts,
pubmed-meshheading:7561234-Peptide Fragments,
pubmed-meshheading:7561234-Phosphorus,
pubmed-meshheading:7561234-Procollagen,
pubmed-meshheading:7561234-Tumor Markers, Biological
|
| pubmed:articleTitle |
Serum levels of procollagen type I carboxyterminal extension peptide in cancer patients with bone metastases.
|
| pubmed:affiliation |
IV Department of Medicine, Geriatric Institute Pio Albergo Trivulzio, Milano, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|