Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-11-3
|
| pubmed:abstractText |
To facilitate design of vaccine trials, malaria was studied in 6-month- to 6-year-old Kenyans during high (HI) and low intensity transmission seasons. During 84 days after cure, exposure to infected mosquitoes was 9-fold greater in the HI group, yet incidence of P. falciparum infection was increased only 2-fold, with no age effect. The density of recurrent P. falciparum was 14-fold greater in the HI group, and there was a striking association between age and parasitemia > or = 5000/microL. Fever was the only clinical manifestation attributable to parasitemia and only when the parasite density was > or = 5000/microL. Sixty-four percent of children with > or = 20,000 parasites/microL versus 10% with 1-4999/microL were febrile when parasitemic. Recurrent P. falciparum infection as a vaccine trial end point can be studied year-round among children < or = 6 years [corrected] in western Kenya. However, high-grade parasitemia (> or = 5000 or 20,000/microL) with or without elevated temperature will be optimally studied in the high transmission season among children < 2 years.
|
| pubmed:grant | |
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
172
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1047-54
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7561179-Age Factors,
pubmed-meshheading:7561179-Animals,
pubmed-meshheading:7561179-Anopheles,
pubmed-meshheading:7561179-Antimalarials,
pubmed-meshheading:7561179-Child,
pubmed-meshheading:7561179-Child, Preschool,
pubmed-meshheading:7561179-Clinical Trials as Topic,
pubmed-meshheading:7561179-Cohort Studies,
pubmed-meshheading:7561179-Disease Transmission, Infectious,
pubmed-meshheading:7561179-Fever,
pubmed-meshheading:7561179-Humans,
pubmed-meshheading:7561179-Incidence,
pubmed-meshheading:7561179-Infant,
pubmed-meshheading:7561179-Insect Vectors,
pubmed-meshheading:7561179-Kenya,
pubmed-meshheading:7561179-Malaria, Falciparum,
pubmed-meshheading:7561179-Malaria Vaccines,
pubmed-meshheading:7561179-Parasitemia,
pubmed-meshheading:7561179-Pyrimethamine,
pubmed-meshheading:7561179-Recurrence,
pubmed-meshheading:7561179-Research Design,
pubmed-meshheading:7561179-Retrospective Studies,
pubmed-meshheading:7561179-Rural Population,
pubmed-meshheading:7561179-Seasons,
pubmed-meshheading:7561179-Sulfadoxine
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Impact of transmission intensity and age on Plasmodium falciparum density and associated fever: implications for malaria vaccine trial design.
|
| pubmed:affiliation |
Malaria Program, Naval Medical Research Institute, Rockville, MD 20852, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|