| pubmed-article:7556983 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C1556094 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0000786 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0035724 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0442592 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C0733755 | lld:lifeskim |
| pubmed-article:7556983 | lifeskim:mentions | umls-concept:C1547429 | lld:lifeskim |
| pubmed-article:7556983 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7556983 | pubmed:dateCreated | 1995-11-13 | lld:pubmed |
| pubmed-article:7556983 | pubmed:abstractText | Mitochondrial DNA is exclusively maternally inherited. We recently found the prevalence of diabetic patients with an A to G transition at position 3243 of leucine tRNA (3243 base pair (bp) mutation) to be nearly 1% in randomly selected Japanese subjects. Here, we report the higher prevalence of diabetic patients with the 3243 bp mutation in a specific Japanese population of women attending a diabetic pregnancy clinic. Of 102 patients with non-insulin-dependent diabetes mellitus 6 (5.9%) were positive for the mutation, 1 (8.3%) of 12 patients with gestational diabetes and 2 (5.9%) out of 34 borderline diabetic patients. In contrast, none of 64 patients (0%) with insulin-dependent diabetes mellitus had the 3243 bp mutation. Moreover, there was a difference in the prevalence of spontaneous abortions between patients with and without this mutation (27.3 vs 12.4%). Among nine probands with the mutation, four had a history of one spontaneous abortion (p = 0.0518) and two had a history of two abortions (p = 0.0479). Two probands had a spontaneous abortion even while under strict diabetic metabolic control. The 3243 bp mutation thus may cause spontaneous abortion during pregnancy. | lld:pubmed |
| pubmed-article:7556983 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7556983 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7556983 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7556983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7556983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7556983 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7556983 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7556983 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7556983 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:ShimizuMM | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:OmoriYY | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:KadowakiTT | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:UchigataYY | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:YanagisawaKK | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:SakuraHH | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:SanakaMM | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:MineiSS | lld:pubmed |
| pubmed-article:7556983 | pubmed:author | pubmed-author:KanamuroRR | lld:pubmed |
| pubmed-article:7556983 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7556983 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:7556983 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7556983 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7556983 | pubmed:pagination | 809-15 | lld:pubmed |
| pubmed-article:7556983 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
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| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
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| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:meshHeading | pubmed-meshheading:7556983-... | lld:pubmed |
| pubmed-article:7556983 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7556983 | pubmed:articleTitle | Mutation in the mitochondrial tRNA(leu) at position 3243 and spontaneous abortions in Japanese women attending a clinic for diabetic pregnancies. | lld:pubmed |
| pubmed-article:7556983 | pubmed:affiliation | Diabetes Center, Tokyo Women's Medical College, Japan. | lld:pubmed |
| pubmed-article:7556983 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7556983 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7556983 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
