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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1995-11-13
|
| pubmed:abstractText |
Mitochondrial DNA is exclusively maternally inherited. We recently found the prevalence of diabetic patients with an A to G transition at position 3243 of leucine tRNA (3243 base pair (bp) mutation) to be nearly 1% in randomly selected Japanese subjects. Here, we report the higher prevalence of diabetic patients with the 3243 bp mutation in a specific Japanese population of women attending a diabetic pregnancy clinic. Of 102 patients with non-insulin-dependent diabetes mellitus 6 (5.9%) were positive for the mutation, 1 (8.3%) of 12 patients with gestational diabetes and 2 (5.9%) out of 34 borderline diabetic patients. In contrast, none of 64 patients (0%) with insulin-dependent diabetes mellitus had the 3243 bp mutation. Moreover, there was a difference in the prevalence of spontaneous abortions between patients with and without this mutation (27.3 vs 12.4%). Among nine probands with the mutation, four had a history of one spontaneous abortion (p = 0.0518) and two had a history of two abortions (p = 0.0479). Two probands had a spontaneous abortion even while under strict diabetic metabolic control. The 3243 bp mutation thus may cause spontaneous abortion during pregnancy.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0012-186X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
809-15
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7556983-Abortion, Spontaneous,
pubmed-meshheading:7556983-Adult,
pubmed-meshheading:7556983-Age of Onset,
pubmed-meshheading:7556983-Blood Glucose,
pubmed-meshheading:7556983-Diabetes, Gestational,
pubmed-meshheading:7556983-Diabetes Mellitus, Type 1,
pubmed-meshheading:7556983-Diabetes Mellitus, Type 2,
pubmed-meshheading:7556983-Female,
pubmed-meshheading:7556983-Glucose Tolerance Test,
pubmed-meshheading:7556983-Humans,
pubmed-meshheading:7556983-Insulin,
pubmed-meshheading:7556983-Islets of Langerhans,
pubmed-meshheading:7556983-Japan,
pubmed-meshheading:7556983-Male,
pubmed-meshheading:7556983-Pedigree,
pubmed-meshheading:7556983-Point Mutation,
pubmed-meshheading:7556983-Prediabetic State,
pubmed-meshheading:7556983-Pregnancy,
pubmed-meshheading:7556983-Pregnancy in Diabetics,
pubmed-meshheading:7556983-Prevalence,
pubmed-meshheading:7556983-RNA, Transfer, Leu
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Mutation in the mitochondrial tRNA(leu) at position 3243 and spontaneous abortions in Japanese women attending a clinic for diabetic pregnancies.
|
| pubmed:affiliation |
Diabetes Center, Tokyo Women's Medical College, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|