Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1995-10-30
pubmed:databankReference
pubmed:abstractText
The developing hindbrain is segmented in a series of repetitive bulges called neuromeres or rhombomeres. In the mouse, first molecular evidence for segmentation of the hindbrain came from rhombomeres 3- and 5-specific expression of the Krox-20 gene. The hindbrain segments are linked with the expression of different Hox genes which have a role in patterning the hindbrain and branchial region of the vertebrate head. Here we identified by subtractive hybridization a gene, mouse neuronatin, that is downregulated in P19 embryo carcinoma cells that have undergone a partial differentiation process. Neuronatin encodes putative transmembrane proteins of 54, 55, and 81 amino acids that might serve as protein ligands, cofactors, or small cell adhesion molecules. The neuronatin gene is transiently expressed in rhombomeres 3 and 5 during early hindbrain development and in the floor of the foregut pocket. In addition, expression is observed in the early Rathke's pouch, in the derived adenohypophysis, and in the developing inner ear. During later embryogenesis the neuronatin gene is strongly expressed in the major part of the central and peripheral nervous system. These results suggest that neuronatin participates in the maintenance of segment identity in the hindbrain and pituitary development and maturation or maintenance of the overall structure of the nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-1606
pubmed:author
pubmed:issnType
Print
pubmed:volume
171
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-84
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:7556909-Alternative Splicing, pubmed-meshheading:7556909-Amino Acid Sequence, pubmed-meshheading:7556909-Animals, pubmed-meshheading:7556909-Base Sequence, pubmed-meshheading:7556909-Cell Differentiation, pubmed-meshheading:7556909-Cell Line, Transformed, pubmed-meshheading:7556909-DNA, Complementary, pubmed-meshheading:7556909-Gene Expression Regulation, Developmental, pubmed-meshheading:7556909-Membrane Proteins, pubmed-meshheading:7556909-Mice, pubmed-meshheading:7556909-Molecular Sequence Data, pubmed-meshheading:7556909-Neoplastic Stem Cells, pubmed-meshheading:7556909-Nerve Tissue Proteins, pubmed-meshheading:7556909-Neural Crest, pubmed-meshheading:7556909-Peripheral Nervous System, pubmed-meshheading:7556909-Pituitary Gland, pubmed-meshheading:7556909-RNA, Messenger, pubmed-meshheading:7556909-Rhombencephalon, pubmed-meshheading:7556909-Sequence Homology, Amino Acid, pubmed-meshheading:7556909-Spinal Cord
pubmed:year
1995
pubmed:articleTitle
Segment-specific expression of the neuronatin gene during early hindbrain development.
pubmed:affiliation
Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Am Fassberg, Göttingen, Germany.
pubmed:publicationType
Journal Article