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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1995-11-2
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pubmed:abstractText |
The ubiquitous distribution of many contaminants and the nonlethal, multigenerational effects of such contaminants on reproductive, endocrine, and immune systems have led to concerns that wildlife worldwide are affected. Although the causal agents and effects are known for some species, the underlying physiological mechanisms associated with contaminant-induced reproductive modifications are still poorly understood and require extensive research. We describe a study examining the steroidogenic activity of gonads removed from juvenile alligators (Alligator mississippiensis) obtained from contaminated or control lakes in central Florida. Synthesis of estradiol-17 beta (E2) was significantly different when ovaries from the contaminated and control lakes were compared in vitro. Additionally, testes from males obtained from the contaminated lake. Lake Apopka, synthesized significantly higher concentrations of E2 when compared to testes obtained from control males. In contrast, testosterone (T) synthesis from all testes examined in this study displayed a normal pattern and produced concentrations greater than that observed from ovaries obtained from either lake. Interestingly, the pattern of gonadal steroidogenesis differs from previously reported plasma concentrations of these hormones obtained from the same individuals. We suggest that the differences between the in vivo and in vitro patterns are due to modifications in the hepatic degradation of plasma sex steroid hormones.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-1378305,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-1645482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-1806141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-2172995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-3026405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-3569844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-3764917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-4634002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-499079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-6188376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-6265492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-6404510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-6777238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-7194202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-7556030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-7895709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-8080506,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7556021-8119246
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0091-6765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
103 Suppl 4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7556021-Alligators and Crocodiles,
pubmed-meshheading:7556021-Animals,
pubmed-meshheading:7556021-Estradiol,
pubmed-meshheading:7556021-Female,
pubmed-meshheading:7556021-Florida,
pubmed-meshheading:7556021-Fresh Water,
pubmed-meshheading:7556021-Male,
pubmed-meshheading:7556021-Ovary,
pubmed-meshheading:7556021-Radioimmunoassay,
pubmed-meshheading:7556021-Testis,
pubmed-meshheading:7556021-Testosterone,
pubmed-meshheading:7556021-Water Pollutants
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pubmed:year |
1995
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pubmed:articleTitle |
Gonadal steroidogenesis in vitro from juvenile alligators obtained from contaminated or control lakes.
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pubmed:affiliation |
Department of Zoology, University of Florida, Gainesville 32611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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