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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0007634,
umls-concept:C0026367,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0871261,
umls-concept:C1441616,
umls-concept:C1510420,
umls-concept:C1512656,
umls-concept:C1521827,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2603343,
umls-concept:C2911692
|
| pubmed:issue |
1-4
|
| pubmed:dateCreated |
1995-11-6
|
| pubmed:abstractText |
Responses of immunocompetent cells, especially class II major histocompatibility complex (MHC) antigen-expressing cells, were investigated after cavity preparation in the erupted upper first molar teeth of rats, by immunohistochemistry using OX6-monoclonal antibody. In control teeth, OX6-immunopositive cells were predominantly located beneath the odontoblast layer in the dental pulp. Cavity preparation caused an acute edematous reaction between the injured odontoblasts and predentin, and most of OX6-immunopositive cells in the affected site shifted away from the pulp-dentin border. After 12-24 hours, many OX6-immunopositive cells accumulated along the pulp-dentin border and extended their cytoplasmic processes into the exposed dentinal tubules. After 72 hours, newly differentiated odontoblasts replaced the degenerated odontoblasts, and few OX6-immunopositive cells remained along the pulp-dentin border. Our data suggest that some of the class II MHC antigen-expressing cells in the dental pulp participate in the initial defense reaction and presumably serve as a biological sensor for the external stimuli arriving through the exposed dentinal tubules.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0300-8207
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
303-11
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:7554932-Animals,
pubmed-meshheading:7554932-Antibodies, Monoclonal,
pubmed-meshheading:7554932-B-Lymphocytes,
pubmed-meshheading:7554932-Cell Differentiation,
pubmed-meshheading:7554932-Cytoplasm,
pubmed-meshheading:7554932-Dendritic Cells,
pubmed-meshheading:7554932-Dental Cavity Preparation,
pubmed-meshheading:7554932-Dental Pulp,
pubmed-meshheading:7554932-Dental Pulp Diseases,
pubmed-meshheading:7554932-Dentin,
pubmed-meshheading:7554932-Edema,
pubmed-meshheading:7554932-Female,
pubmed-meshheading:7554932-Histocompatibility Antigens Class II,
pubmed-meshheading:7554932-Immunohistochemistry,
pubmed-meshheading:7554932-Molar,
pubmed-meshheading:7554932-Odontoblasts,
pubmed-meshheading:7554932-Rats,
pubmed-meshheading:7554932-Rats, Wistar,
pubmed-meshheading:7554932-T-Lymphocytes
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Responses of immunocompetent cells to cavity preparation in rat molars: an immunohistochemical study using OX6-monoclonal antibody.
|
| pubmed:affiliation |
Second Department of Oral Anatomy, Niigata University School of Dentistry, Japan.
|
| pubmed:publicationType |
Journal Article
|