| pubmed-article:7554396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C1518997 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7554396 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7554396 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7554396 | pubmed:dateCreated | 1995-11-7 | lld:pubmed |
| pubmed-article:7554396 | pubmed:abstractText | Infection of immune cells with HIV induces dysregulation of cytokines which may play a vital role in HIV pathogenesis. We analysed the expression of T helper type 1 (Th1) (interferon-gamma (IFN-gamma)) and Th2 (IL-4, IL-10) type cytokines in peripheral blood lymphocytes (PBL) from HIV+ patients. The semiquantitative reverse transcriptase polymerase chain reaction (RT-PCR) analysis revealed that IFN-gamma mRNA in unstimulated PBL was significantly decreased and IL-10 mRNA was significantly upregulated in patients with < 400 CD4+ T cells/mm3 (n = 30) as compared to patients with > 400 CD4+ T cells/mm3 (n = 6) and normal controls (n = 16). In addition, IL-10 mRNA levels were inversely associated with IFN-gamma expression. Similar results were obtained by measuring IL-10 production in the supernatants of PBL cultured in vitro without stimulation by employing an enzyme immunosorbent assay (ELISA). However, the levels of IL-4 and IFN-gamma produced by unstimulated PBL were undetectable by ELISA. Mitogen stimulation of PBL revealed two groups of HIV+ individuals based on IL-10 production. PBL from one set of individuals produced low levels of IL-10 (low IL-10 producers) whereas the other group produced IL-10 comparable to that of normal controls (IL-10 producers). Production of IL-4 was significantly reduced in HIV+ individuals with < 400 CD4+ T cells/mm3 as compared to the normal controls. However, ability to produce IFN-gamma by mitogen-stimulated total PBL and CD4+ purified cells was not impaired in HIV+ individuals. These results suggest that unstimulated and mitogen-stimulated PBL of HIV+ individuals exhibit dysregulation of Th2 type cytokines which may play a role in HIV immunopathogenesis. | lld:pubmed |
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| pubmed-article:7554396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7554396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554396 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7554396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7554396 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7554396 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:KumarAA | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:Diaz-MitomaFF | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:FilionL GLG | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:CameronWW | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:KarimiSS | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:DaftarianM... | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:KryworuchkoMM | lld:pubmed |
| pubmed-article:7554396 | pubmed:author | pubmed-author:CreeryW DWD | lld:pubmed |
| pubmed-article:7554396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7554396 | pubmed:volume | 102 | lld:pubmed |
| pubmed-article:7554396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7554396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7554396 | pubmed:pagination | 31-9 | lld:pubmed |
| pubmed-article:7554396 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7554396 | pubmed:meshHeading | pubmed-meshheading:7554396-... | lld:pubmed |
| pubmed-article:7554396 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7554396 | pubmed:articleTitle | Expression of IL-10, IL-4 and interferon-gamma in unstimulated and mitogen-stimulated peripheral blood lymphocytes from HIV-seropositive patients. | lld:pubmed |
| pubmed-article:7554396 | pubmed:affiliation | Department of Paediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Canada. | lld:pubmed |
| pubmed-article:7554396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7554396 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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