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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1995-11-13
|
| pubmed:abstractText |
A novel cinnamoyl-hexahydrodibenzofuran derivative (1) was isolated from the bark of Lindera umbellata. The structure was determined by extensive spectroscopic analysis to be (5aR*,6R*,9R*,9aS*)-4-cinnamoyl-3,6-dihydroxy-1-methoxy-6-me thyl- 9-(1-methylethyl)-5a,6,7,8,9,9a-hexahydrodibenzofuran. Compound 1 showed potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells without causing any cytotoxicity in the cultured cells or skin irritation in guinea pig.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0009-2363
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
893-5
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:7553975-Animals,
pubmed-meshheading:7553975-Benzofurans,
pubmed-meshheading:7553975-Chemistry, Physical,
pubmed-meshheading:7553975-Guinea Pigs,
pubmed-meshheading:7553975-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7553975-Melanins,
pubmed-meshheading:7553975-Melanoma, Experimental,
pubmed-meshheading:7553975-Physicochemical Phenomena,
pubmed-meshheading:7553975-Plant Extracts,
pubmed-meshheading:7553975-Skin,
pubmed-meshheading:7553975-Trees,
pubmed-meshheading:7553975-Tumor Cells, Cultured
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
A novel hexahydrodibenzofuran derivative with potent inhibitory activity on melanin biosynthesis of cultured B-16 melanoma cells from Lindera umbellata bark.
|
| pubmed:affiliation |
School of Pharmacy, Tokyo University of Pharmacy and Life Science, Japan.
|
| pubmed:publicationType |
Journal Article
|