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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-11-20
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pubmed:abstractText |
Alterations of the human MSH2 gene, a homologue of the bacterial MutS mismatch repair gene, co-segregate with the majority of hereditary non-polyposis colon cancer (HNPCC) cases. We have generated homozygous MSH2-/- mice. Surprisingly, these mice were found to be viable, produced offspring in a mendelian ratio and bred through at least two generations. Starting at two months of age homozygous-/- mice began, with high frequency, to develop lymphoid tumours that contained microsatellite instabilities. These data establish a direct link between MSH2 deficiency and the pathogenesis of cancer. These mutant mice should be good models to study the progression of tumours and also to screen carcinogenic and anti-cancer agents.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
64-70
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pubmed:dateRevised |
2009-7-24
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pubmed:meshHeading |
pubmed-meshheading:7550317-Animals,
pubmed-meshheading:7550317-Base Sequence,
pubmed-meshheading:7550317-Cell Transformation, Neoplastic,
pubmed-meshheading:7550317-Colorectal Neoplasms, Hereditary Nonpolyposis,
pubmed-meshheading:7550317-DNA, Neoplasm,
pubmed-meshheading:7550317-DNA, Satellite,
pubmed-meshheading:7550317-DNA Repair,
pubmed-meshheading:7550317-DNA-Binding Proteins,
pubmed-meshheading:7550317-Female,
pubmed-meshheading:7550317-Fungal Proteins,
pubmed-meshheading:7550317-Gene Targeting,
pubmed-meshheading:7550317-Genotype,
pubmed-meshheading:7550317-Humans,
pubmed-meshheading:7550317-Lymphoid Tissue,
pubmed-meshheading:7550317-Male,
pubmed-meshheading:7550317-Meiosis,
pubmed-meshheading:7550317-Mice,
pubmed-meshheading:7550317-Mice, Knockout,
pubmed-meshheading:7550317-Mice, Mutant Strains,
pubmed-meshheading:7550317-Molecular Sequence Data,
pubmed-meshheading:7550317-MutS Homolog 2 Protein,
pubmed-meshheading:7550317-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:7550317-Species Specificity
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pubmed:year |
1995
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pubmed:articleTitle |
MSH2 deficient mice are viable and susceptible to lymphoid tumours.
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pubmed:affiliation |
Amgen Institute, Department of Medical Biophysics, University of Toronto, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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