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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1995-11-6
|
| pubmed:abstractText |
beta-Eudesmol, a sesquiterpenoid alcohol contained in Atractylodes lancea, potentiates succinylcholine (SuCh)-induced neuromuscular blockade. The potentiating effect is greater in diabetic muscles than in normal ones. As a ligand for affinity chromatography to study the potentiating mechanism, we designed and synthesized newly beta-eudesmol-related cyclohexylidene derivatives (2-(3-hydroxy-3-methylbutyl)cyclohexylidene; KTE-13, 2-(3-hydroxy-3-methylbutyl)-4-cyclohexylidene carboxylic acid; KTE-32 and 4-tert-butoxycarbonyl-2-(3-hydroxy-3-methylbutyl) cyclohexylidene; KTE-33). We examined the potentiating effects of those compounds in phrenic nerve-diaphragm muscle preparations of normal and alloxan-diabetic mice. KTE-33 (100 microM) potentiated more greatly SuCh-induced neuromuscular blockade in diabetic muscles than in normal ones (the potentiating ratios in normal and diabetic muscles were 6.7 and 10.6, respectively), while KTE-13 (100 microM) and -32 (200 microM) potentiated weakly. These results suggest that the ester group in KTE-33 rather than a carboxyl group in KTE-32 is important in inducing the potentiation of SuCh-induced neuromuscular blockade in diabetic state.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanes,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Neuromuscular Blocking Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes, Eudesmane,
http://linkedlifedata.com/resource/pubmed/chemical/Succinylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/beta-eudesmol
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0918-6158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
407-10
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7550092-Animals,
pubmed-meshheading:7550092-Cyclohexanes,
pubmed-meshheading:7550092-Diabetes Mellitus, Experimental,
pubmed-meshheading:7550092-Diaphragm,
pubmed-meshheading:7550092-Drug Synergism,
pubmed-meshheading:7550092-Drugs, Chinese Herbal,
pubmed-meshheading:7550092-Male,
pubmed-meshheading:7550092-Mice,
pubmed-meshheading:7550092-Mice, Inbred Strains,
pubmed-meshheading:7550092-Muscle Contraction,
pubmed-meshheading:7550092-Neuromuscular Blocking Agents,
pubmed-meshheading:7550092-Neuromuscular Junction,
pubmed-meshheading:7550092-Phrenic Nerve,
pubmed-meshheading:7550092-Sesquiterpenes, Eudesmane,
pubmed-meshheading:7550092-Stimulation, Chemical,
pubmed-meshheading:7550092-Succinylcholine,
pubmed-meshheading:7550092-Synaptic Transmission,
pubmed-meshheading:7550092-Terpenes
|
| pubmed:year |
1995
|
| pubmed:articleTitle |
Potentiating effects of beta-eudesmol-related cyclohexylidene derivatives on succinylcholine-induced neuromuscular block in isolated phrenic nerve-diaphragm muscles of normal and alloxan-diabetic mice.
|
| pubmed:affiliation |
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
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| pubmed:publicationType |
Journal Article
|