Linked Life Data

7549411

Source:http://linkedlifedata.com/resource/pubmed/id/7549411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1995-11-9
pubmed:abstractText
It is well established that caffeine and alcohol can have acute effects on heart rate and blood pressure, but it is not known whether cardiac output and peripheral blood flow are also affected. Such information is needed before any possible effects of caffeine or alcohol on the haemodynamic responses to food can be assessed. Thus, the present study determined the haemodynamic effects of caffeine or alcohol. Eight healthy young subjects were studied in the fasting state before and after ingestion of water (200 ml), coffee containing caffeine (3.5 mg/kg in 200 ml) or alcohol (0.5 g/kg made up to 200 ml), in random order on three separate occasions. All of the subjects had abstained from both caffeine and alcohol for at least 12 h. Measurements of blood pressure (BP), heart rate (HR), cardiac output (CO), superior mesenteric artery blood flow (SMABF) and calf blood flow (CBF) were made at baseline and for 2 h after each drink. With the alcohol drink, blood alcohol levels estimated using breath measurement peaked at 18.8 mmol/l. HR fell slightly after water but increased after alcohol (+ 7 beats/min) and after caffeine (+ 16 beats/min, group x time interaction analysis of variance, p < 0.03), with peak responses at 40-60 min and a return to baseline by 120 min. Systolic BP increased significantly with time after all three drinks, with no significant differences between the drinks. CBF rose slightly after the drink of water, more so after alcohol but fell slightly after caffeine (group x time interaction analysis of variance, p < 0.01).
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0959-9851
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Systemic and regional haemodynamic effects of caffeine and alcohol in fasting subjects [corrected].
pubmed:affiliation
Department of Physiology and Pharmacology, University of Nottingham Medical School, UK.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't