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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1995-11-8
|
| pubmed:abstractText |
Endogenously induced protoporphyrin IX (PPIX), a metabolite of delta-aminolaevulinic acid (ALA), has been evaluated as a photosensitising agent for destruction of papillomas in cottontail rabbit papillomavirus-infected Dutch belted and New Zealand rabbits. Three factors were evaluated: (1) relative retention ratio of drug in normal tissue, papilloma and plasma over time; (2) tissue tolerance to treatment factors; and (3) efficacy of treatment protocol. Three drug doses of ALA were examined: 50, 100 and 200 mg kg-1. Actual PPIX concentrations in tissue and plasma were determined spectrophotofluorometrically. The optimal treatment time occurred 3-6 h post ALA injection. The highest PPIX concentration ratio between papilloma and normal skin was 6:1. Different light doses were investigated, using an injection to exposure interval of 3 h and an irradiance of 100 mW cm-2 at a wavelength of 630 nm. Efficacy without risk of significant damage to normal skin was obtained using 100-200 mg kg-1 ALA and 40-60 J cm-2. A long-term (3 months) cure rate of 82% was obtained with a single treatment, provided that papilloma depth did not exceed 8 mm, volume was not more than 1000 mm3 and the plasma concentration of PPIX immediately before exposure was above 500 micrograms ml-1. The short time between injection and treatment and high efficacy, together with PPIX disappearance from plasma and tissue within 24 h, make injected ALA a highly attractive drug for photodynamic therapy.
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| pubmed:grant | |
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-1089001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-1399120,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-1403373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-14200253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-1616853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-1764375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-2144033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-2775215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-2948536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-3581053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-3809258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-4983317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-6280459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-6497856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-712211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-7687318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-7980901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-8123497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-8318069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7547231-8318419
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0007-0920
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
857-64
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1995
|
| pubmed:articleTitle |
Efficacy of intravenous delta-aminolaevulinic acid photodynamic therapy on rabbit papillomas.
|
| pubmed:affiliation |
Department of Otolaryngology, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|