Linked Life Data

7546655

Source:http://linkedlifedata.com/resource/pubmed/id/7546655

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1995-10-26
pubmed:abstractText
Up to now, no effective vaccine is available against shigellosis, a dysenteric syndrome caused by Shigella, a Gram-negative bacterium which invades the human colonic mucosa. About 40 years of research in the field have led to the conclusion that orally administered live Shigella vaccine strains are more effective in eliciting protection than killed bacteria given parenterally. Recently, the construction of promising new live attenuated vaccines has come with a better understanding of the fundamental determinants governing pathogenesis. As the development of new vaccine strategies requires knowledge of both pathogenesis and the immune response against infection, the current view of the pathogenic process of Shigella infection and the anti-Shigella immune responses elicited by the host are presented. The attempts in Shigella vaccine design are reviewed and, the future of these vaccines discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1045-1056
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
125-34
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Live attenuated Shigella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery.
pubmed:affiliation
Unité de Pathogénie Microbienne Moléculaire, Inserm U 389 Institut Pasteur, Paris, France.
pubmed:publicationType
Journal Article, Review