rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5171
|
pubmed:dateCreated |
1994-8-15
|
pubmed:databankReference |
|
pubmed:abstractText |
When nutrients become limiting, many bacteria differentiate and become resistant to environmental stresses. For Escherichia coli, this process is mediated by the sigma s subunit of RNA polymerase. Expression of sigma s was induced by homoserine lactone, a metabolite synthesized from intermediates in threonine biosynthesis. Homoserine lactone-dependent synthesis of sigma s was prevented by overexpression of a newly identified protein, RspA. The function of homoserine lactone derivatives in many cell density-dependent phenomena and the similarity of RspA to a Streptomyces ambofaciens protein suggest that synthesis of homoserine lactone may be a general signal of starvation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0036-8075
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
22
|
pubmed:volume |
265
|
pubmed:geneSymbol |
rpoS,
rspA
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
537-9
|
pubmed:dateRevised |
2007-3-19
|
pubmed:meshHeading |
pubmed-meshheading:7545940-4-Butyrolactone,
pubmed-meshheading:7545940-Amino Acid Sequence,
pubmed-meshheading:7545940-Bacterial Proteins,
pubmed-meshheading:7545940-Catalase,
pubmed-meshheading:7545940-Escherichia coli,
pubmed-meshheading:7545940-Gene Expression Regulation, Bacterial,
pubmed-meshheading:7545940-Models, Biological,
pubmed-meshheading:7545940-Molecular Sequence Data,
pubmed-meshheading:7545940-Operon,
pubmed-meshheading:7545940-Phenotype,
pubmed-meshheading:7545940-Sigma Factor,
pubmed-meshheading:7545940-Signal Transduction,
pubmed-meshheading:7545940-Transcription, Genetic,
pubmed-meshheading:7545940-Vibrio
|
pubmed:year |
1994
|
pubmed:articleTitle |
Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.
|
pubmed:affiliation |
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|