| pubmed-article:7545016 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0329040 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0051318 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C1550548 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C1555714 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C1705654 | lld:lifeskim |
| pubmed-article:7545016 | lifeskim:mentions | umls-concept:C0205812 | lld:lifeskim |
| pubmed-article:7545016 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7545016 | pubmed:dateCreated | 1995-10-10 | lld:pubmed |
| pubmed-article:7545016 | pubmed:abstractText | Small subsets of central neurons possessing Ca2+ permeable AMPA/kainate channels can be identified by a histochemical stain based on kainate-stimulated Co2+ uptake (Co2+(+)neurons) and are unusually vulnerable to AMPA/kainate receptor-mediated injury. Using brief kainate exposures (which selectively destroy Co2+(+) neurons) along with kainate triggered 45Ca2+ influx measurements, we estimate kainate to cause an unusually high rate of Ca2+ influx into Co2+(+) neurons. Also, while fura-2 Ca2+ imaging revealed low (10 microM) kainate exposures to preferentially induce intracellular free Ca2+ ([Ca2+]i) elevations in Co2+(+) neurons, intense (100 microM) kainate exposures used in the 45Ca2+ influx studies triggered comparable [Ca2+]i rises in all neurons. These findings suggest that the exceptional vulnerability of Co2+(+) neurons to AMPA/kainate receptor-mediated injury reflects a high rate of agonist triggered Ca2+ influx, and that [Ca2+]i rises may only poorly reflect influx rate. | lld:pubmed |
| pubmed-article:7545016 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7545016 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7545016 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7545016 | pubmed:month | May | lld:pubmed |
| pubmed-article:7545016 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:7545016 | pubmed:author | pubmed-author:LoY SYS | lld:pubmed |
| pubmed-article:7545016 | pubmed:author | pubmed-author:WeissJ HJH | lld:pubmed |
| pubmed-article:7545016 | pubmed:author | pubmed-author:YinH ZHZ | lld:pubmed |
| pubmed-article:7545016 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7545016 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:7545016 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:7545016 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7545016 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7545016 | pubmed:pagination | 1089-92 | lld:pubmed |
| pubmed-article:7545016 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
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| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:meshHeading | pubmed-meshheading:7545016-... | lld:pubmed |
| pubmed-article:7545016 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7545016 | pubmed:articleTitle | Ca2+ permeable AMPA/kainate channels permit rapid injurious Ca2+ entry. | lld:pubmed |
| pubmed-article:7545016 | pubmed:affiliation | Department of Neurology, University of California, Irvine 92717-4290, USA. | lld:pubmed |
| pubmed-article:7545016 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7545016 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7545016 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
