| pubmed-article:7544544 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C0034837 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C0017070 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C1522565 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:7544544 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7544544 | pubmed:issue | 2 Pt 2 | lld:pubmed |
| pubmed-article:7544544 | pubmed:dateCreated | 1995-9-22 | lld:pubmed |
| pubmed-article:7544544 | pubmed:abstractText | Effects elicited by adenosine and substance P on ventricular sensory endings of 14 dorsal root ganglion afferent neurons were studied in situ in anesthetized dogs. Sensory-field application of adenosine (1 microM) increased the activity of these neurons by 179%. Application of a nonspecific adenosine antagonist to epicardial sensory fields suppressed ongoing activity in all 14 neurons by 39%. Application of an A1- or A2-adenosine-receptor antagonist suppressed activity generated by 10 of these neurons by 44 and 59%, respectively. Adenosine applied after A1- or A2-receptor blockade increased activity in 10 neurons by 131 and 145%, respectively, indicating that A1- and A2-receptor effects were not additive. Application of substance P (1 microM) to identified sensory fields increased activity in 12 of these neurons by 169%, whereas application of a substance P-receptor antagonist reduced activity generated by these neurons by 75%. Myocardial ischemia increased activity of nine neurons associated with left ventricular sensory fields by 320%, an effect that was counteracted by the nonspecific adenosine-receptor antagonist. It is concluded that A1- and A2-adenosine receptors, as well as substance P receptors, are present on ventricular epicardial sensory nerve endings of dorsal root ganglion neurons that are tonically active during normal states, becoming further activated during ischemia. | lld:pubmed |
| pubmed-article:7544544 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7544544 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7544544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7544544 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7544544 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7544544 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:7544544 | pubmed:author | pubmed-author:SylvénCC | lld:pubmed |
| pubmed-article:7544544 | pubmed:author | pubmed-author:HorackovaMM | lld:pubmed |
| pubmed-article:7544544 | pubmed:author | pubmed-author:HuangM HMH | lld:pubmed |
| pubmed-article:7544544 | pubmed:author | pubmed-author:ArmourJ AJA | lld:pubmed |
| pubmed-article:7544544 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7544544 | pubmed:volume | 269 | lld:pubmed |
| pubmed-article:7544544 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7544544 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7544544 | pubmed:pagination | R318-24 | lld:pubmed |
| pubmed-article:7544544 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:meshHeading | pubmed-meshheading:7544544-... | lld:pubmed |
| pubmed-article:7544544 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7544544 | pubmed:articleTitle | Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P. | lld:pubmed |
| pubmed-article:7544544 | pubmed:affiliation | Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. | lld:pubmed |
| pubmed-article:7544544 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7544544 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7544544 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7544544 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7544544 | lld:pubmed |
