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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2 Pt 2
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pubmed:dateCreated |
1995-9-22
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pubmed:abstractText |
Effects elicited by adenosine and substance P on ventricular sensory endings of 14 dorsal root ganglion afferent neurons were studied in situ in anesthetized dogs. Sensory-field application of adenosine (1 microM) increased the activity of these neurons by 179%. Application of a nonspecific adenosine antagonist to epicardial sensory fields suppressed ongoing activity in all 14 neurons by 39%. Application of an A1- or A2-adenosine-receptor antagonist suppressed activity generated by 10 of these neurons by 44 and 59%, respectively. Adenosine applied after A1- or A2-receptor blockade increased activity in 10 neurons by 131 and 145%, respectively, indicating that A1- and A2-receptor effects were not additive. Application of substance P (1 microM) to identified sensory fields increased activity in 12 of these neurons by 169%, whereas application of a substance P-receptor antagonist reduced activity generated by these neurons by 75%. Myocardial ischemia increased activity of nine neurons associated with left ventricular sensory fields by 320%, an effect that was counteracted by the nonspecific adenosine-receptor antagonist. It is concluded that A1- and A2-adenosine receptors, as well as substance P receptors, are present on ventricular epicardial sensory nerve endings of dorsal root ganglion neurons that are tonically active during normal states, becoming further activated during ischemia.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Purinergic P1,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0002-9513
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
269
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R318-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7544544-Adenosine,
pubmed-meshheading:7544544-Animals,
pubmed-meshheading:7544544-Calcium Channel Agonists,
pubmed-meshheading:7544544-Calcium Channel Blockers,
pubmed-meshheading:7544544-Dogs,
pubmed-meshheading:7544544-Female,
pubmed-meshheading:7544544-Ganglia, Spinal,
pubmed-meshheading:7544544-Heart,
pubmed-meshheading:7544544-Heart Ventricles,
pubmed-meshheading:7544544-Male,
pubmed-meshheading:7544544-Myocardial Ischemia,
pubmed-meshheading:7544544-Myocardium,
pubmed-meshheading:7544544-Neurons, Afferent,
pubmed-meshheading:7544544-Pericardium,
pubmed-meshheading:7544544-Receptors, Purinergic P1,
pubmed-meshheading:7544544-Substance P
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pubmed:year |
1995
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pubmed:articleTitle |
Ventricular sensory neurons in canine dorsal root ganglia: effects of adenosine and substance P.
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pubmed:affiliation |
Department of Physiology and Biophysics, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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