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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2-3
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pubmed:dateCreated |
1995-9-22
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pubmed:abstractText |
The transcription of the human tenascin-C (TN-C) gene is directed by a single promoter. Here we demonstrate, in transiently transfected cells, that two distinct regions of the untranslated 179 bp-long exon 1 play antagonistic roles in transcriptional regulation: bases from 1 to 20 strongly increase the transcription of the reporter gene CAT directed by the human TN-C gene promoter, while bases from 79 to 179 significantly reduce this activation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
369
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7544297-3T3 Cells,
pubmed-meshheading:7544297-Animals,
pubmed-meshheading:7544297-Base Sequence,
pubmed-meshheading:7544297-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:7544297-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:7544297-Cricetinae,
pubmed-meshheading:7544297-Enhancer Elements, Genetic,
pubmed-meshheading:7544297-Exons,
pubmed-meshheading:7544297-Extracellular Matrix Proteins,
pubmed-meshheading:7544297-Genes,
pubmed-meshheading:7544297-Genes, Reporter,
pubmed-meshheading:7544297-Humans,
pubmed-meshheading:7544297-Mice,
pubmed-meshheading:7544297-Molecular Sequence Data,
pubmed-meshheading:7544297-Promoter Regions, Genetic,
pubmed-meshheading:7544297-RNA, Messenger,
pubmed-meshheading:7544297-Sequence Homology, Nucleic Acid,
pubmed-meshheading:7544297-Tenascin,
pubmed-meshheading:7544297-Transcription, Genetic,
pubmed-meshheading:7544297-Transfection,
pubmed-meshheading:7544297-Tumor Cells, Cultured
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pubmed:year |
1995
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pubmed:articleTitle |
The first untranslated exon of the human tenascin-C gene plays a regulatory role in gene transcription.
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pubmed:affiliation |
Laboratory of Cell Biology, Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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