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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1995-9-18
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pubmed:abstractText |
We have previously shown that cattle vaccinated with L2, the minor structural protein of bovine papillomavirus-4 (BPV-4), do not develop alimentary papillomas upon challenge with BPV-4. Analysis of the B and T cell response in L2-vaccinated animals showed that the majority of the response was directed against the N-terminus and C-terminus of L2 with little response against the middle portion. Cattle were vaccinated with the N-terminus or the C-terminus of L2. The animals vaccinated with the N-terminus were completely protected from viral challenge, whereas the animals vaccinated with the C-terminus were not. Further analysis with synthetic overlapping peptides spanning the entire N-terminus mapped a B cell immunodominant epitope at amino acid 101-120. This epitope was recognised by all vaccinated animals.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0042-6822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
211
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
204-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7544045-Amino Acid Sequence,
pubmed-meshheading:7544045-Animals,
pubmed-meshheading:7544045-Antibody Formation,
pubmed-meshheading:7544045-B-Lymphocytes,
pubmed-meshheading:7544045-Bovine papillomavirus 1,
pubmed-meshheading:7544045-Bovine papillomavirus 4,
pubmed-meshheading:7544045-Capsid,
pubmed-meshheading:7544045-Capsid Proteins,
pubmed-meshheading:7544045-Cattle,
pubmed-meshheading:7544045-Epitopes,
pubmed-meshheading:7544045-Lymphocyte Activation,
pubmed-meshheading:7544045-Molecular Sequence Data,
pubmed-meshheading:7544045-Open Reading Frames,
pubmed-meshheading:7544045-Papilloma,
pubmed-meshheading:7544045-Papillomavirus Infections,
pubmed-meshheading:7544045-Peptides,
pubmed-meshheading:7544045-Tumor Virus Infections,
pubmed-meshheading:7544045-Vaccines, Synthetic,
pubmed-meshheading:7544045-Viral Structural Proteins,
pubmed-meshheading:7544045-Viral Vaccines
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pubmed:year |
1995
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pubmed:articleTitle |
Vaccination of cattle with the N-terminus of L2 is necessary and sufficient for preventing infection by bovine papillomavirus-4.
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pubmed:affiliation |
Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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