|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
1995-9-14
|
|
pubmed:abstractText |
The induction of a unique macrophage procoagulant molecule by murine hepatitis virus strain 3 correlates with the severity of viral hepatitis. The role of tyrosine phosphorylation in the signalling pathway leading to procoagulant expression was studied. Murine hepatitis virus strain 3 initiated a rapid increase in phosphotyrosine accumulation. Tyrosine kinase inhibition precluded this increase and abrogated expression of the virus-induced procoagulant mouse fibrinogen-like protein (musfiblp) gene. These findings suggest that manipulation of this signalling pathway in vivo might represent a novel approach to treating this disease.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1279203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1281458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1321821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1324969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1381363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1426765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1637321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1666190,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-1719235,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-2160434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-2537311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-3020124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-3106339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-3624490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-380843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-6165771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-6196603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-6270227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-6927856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-7200121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-7609073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-7686943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-7690817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-7693711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8132624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8137930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8191285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8336932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8380065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7543590-8388132
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Catechols,
http://linkedlifedata.com/resource/pubmed/chemical/Genistein,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams, Macrocyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Quinones,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrphostins,
http://linkedlifedata.com/resource/pubmed/chemical/herbimycin,
http://linkedlifedata.com/resource/pubmed/chemical/tyrphostin 47
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
69
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5824-8
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:7543590-Animals,
pubmed-meshheading:7543590-Benzoquinones,
pubmed-meshheading:7543590-Catechols,
pubmed-meshheading:7543590-Cells, Cultured,
pubmed-meshheading:7543590-Female,
pubmed-meshheading:7543590-Genistein,
pubmed-meshheading:7543590-Hepatitis, Viral, Animal,
pubmed-meshheading:7543590-Isoflavones,
pubmed-meshheading:7543590-Kinetics,
pubmed-meshheading:7543590-Lactams, Macrocyclic,
pubmed-meshheading:7543590-Macrophages, Peritoneal,
pubmed-meshheading:7543590-Mice,
pubmed-meshheading:7543590-Murine hepatitis virus,
pubmed-meshheading:7543590-Nitriles,
pubmed-meshheading:7543590-Phosphorylation,
pubmed-meshheading:7543590-Phosphotyrosine,
pubmed-meshheading:7543590-Protein-Tyrosine Kinases,
pubmed-meshheading:7543590-Quinones,
pubmed-meshheading:7543590-Tyrosine,
pubmed-meshheading:7543590-Tyrphostins
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation.
|
|
pubmed:affiliation |
Department of Surgery, University of Toronto, Canada.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
