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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-9-12
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pubmed:abstractText |
IFN-gamma-secreting T1 and IL-5-secreting T2 subsets of CD8 effectors were generated in vitro using freshly isolated cells from wild-type and perforin knockout mice stimulated with allogeneic Ag-presenting cells. Both T1 and T2 effectors from wild-type mice exhibited perforin-mediated cytolysis. T1, but not T2, populations from perforin knockout mice displayed significant lysis by the Fas-mediated pathway. Th1 cells have recently been shown to be regulated by Fas and we speculate that Fas-mediated mechanisms are involved in the regulation of both Th1 and T1 populations of T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1028-31
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7543509-Animals,
pubmed-meshheading:7543509-Antigen-Presenting Cells,
pubmed-meshheading:7543509-Antigens, CD95,
pubmed-meshheading:7543509-Antigens, Surface,
pubmed-meshheading:7543509-CD8-Positive T-Lymphocytes,
pubmed-meshheading:7543509-Cytokines,
pubmed-meshheading:7543509-Cytotoxicity, Immunologic,
pubmed-meshheading:7543509-Egtazic Acid,
pubmed-meshheading:7543509-H-2 Antigens,
pubmed-meshheading:7543509-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:7543509-Male,
pubmed-meshheading:7543509-Membrane Glycoproteins,
pubmed-meshheading:7543509-Mice,
pubmed-meshheading:7543509-Mice, Inbred C57BL,
pubmed-meshheading:7543509-Mice, Knockout,
pubmed-meshheading:7543509-Perforin,
pubmed-meshheading:7543509-Pore Forming Cytotoxic Proteins,
pubmed-meshheading:7543509-T-Lymphocyte Subsets
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pubmed:year |
1995
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pubmed:articleTitle |
Relative perforin- and Fas-mediated lysis in T1 and T2 CD8 effector populations.
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pubmed:affiliation |
Department of Molecular Pathology, University of California San Diego Cancer Center, La Jolla 92093, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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