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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6538
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pubmed:dateCreated |
1995-9-6
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pubmed:abstractText |
CD19 is the hallmark differentiation antigen of the B lineage. Its early expression has implicated a role for CD19 during the antigen-independent phases of B-cell development, whereas in mature B cells CD19 can act synergistically with surface immunoglobulin to induce activation. We have generated CD19-deficient mice and found that development of conventional B cells is unperturbed. However, mature CD19-/- B cells show a profound deficiency in responding to protein antigens that require T-cell help. This is accompanied by a lack of germinal centre formation and affinity maturation of serum antibodies. Thus CD19 is crucial for both initial B-cell activation by T-cell-dependent antigens and the maturation and/or selection of the activated cells into the memory compartment. An impairment in ligand-driven selection may also be responsible for the observation of a striking reduction in the B-1 (formerly Ly-1) B-cell subset, thought to develop under the control of self-antigens and bacterial antigens (reviewed in ref. 2).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
376
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7543183-Animals,
pubmed-meshheading:7543183-Antigens,
pubmed-meshheading:7543183-Antigens, CD,
pubmed-meshheading:7543183-Antigens, CD19,
pubmed-meshheading:7543183-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:7543183-B-Lymphocyte Subsets,
pubmed-meshheading:7543183-B-Lymphocytes,
pubmed-meshheading:7543183-Base Sequence,
pubmed-meshheading:7543183-Bone Marrow Cells,
pubmed-meshheading:7543183-Cell Differentiation,
pubmed-meshheading:7543183-Cells, Cultured,
pubmed-meshheading:7543183-DNA Primers,
pubmed-meshheading:7543183-Flow Cytometry,
pubmed-meshheading:7543183-Hematopoietic Stem Cells,
pubmed-meshheading:7543183-Lymphocyte Activation,
pubmed-meshheading:7543183-Mice,
pubmed-meshheading:7543183-Mice, Inbred BALB C,
pubmed-meshheading:7543183-Molecular Sequence Data,
pubmed-meshheading:7543183-Mutagenesis,
pubmed-meshheading:7543183-Peritoneal Cavity,
pubmed-meshheading:7543183-Spleen,
pubmed-meshheading:7543183-T-Lymphocytes
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pubmed:year |
1995
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pubmed:articleTitle |
Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.
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pubmed:affiliation |
Institute for Genetics, University of Cologne, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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