|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5224
|
|
pubmed:dateCreated |
1995-8-31
|
|
pubmed:abstractText |
An immunoglobulin E (IgE)-dependent histamine-releasing factor (HRF) produced by lymphocytes of atopic children and present in biological fluids of allergic patients has been identified and purified. Amino-terminal sequencing revealed extensive homology to a mouse protein, p21, and its human homolog, p23. Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Polyclonal antibodies recognized and removed the biological activity of recombinant and native HRF. HRF identifies a heterogeneity of IgE and is believed to play a prominent role in chronic allergic disease processes.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
4
|
|
pubmed:volume |
269
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
688-90
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7542803-Amino Acid Sequence,
pubmed-meshheading:7542803-Animals,
pubmed-meshheading:7542803-Antibodies,
pubmed-meshheading:7542803-Base Sequence,
pubmed-meshheading:7542803-Basophils,
pubmed-meshheading:7542803-Cell Line,
pubmed-meshheading:7542803-Cloning, Molecular,
pubmed-meshheading:7542803-Histamine Release,
pubmed-meshheading:7542803-Humans,
pubmed-meshheading:7542803-Immunoglobulin E,
pubmed-meshheading:7542803-Kinetics,
pubmed-meshheading:7542803-Lymphokines,
pubmed-meshheading:7542803-Macrophages,
pubmed-meshheading:7542803-Mice,
pubmed-meshheading:7542803-Molecular Sequence Data,
pubmed-meshheading:7542803-Recombinant Fusion Proteins,
pubmed-meshheading:7542803-Sequence Homology, Amino Acid,
pubmed-meshheading:7542803-Tumor Markers, Biological
|
|
pubmed:year |
1995
|
|
pubmed:articleTitle |
Molecular identification of an IgE-dependent histamine-releasing factor.
|
|
pubmed:affiliation |
Department of Medicine, Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
