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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1995-8-29
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pubmed:abstractText |
Trypsinogen activation peptide (TAP) concentration and alpha 2-macroglobulin-trypsin complex (alpha 2M-T) activity were measured in two experimental models of acute pancreatitis in rats to evaluate the significance of activation of trypsinogen in acute pancreatitis. TAP concentration and alpha 2M-T activity in serum rose significantly in trypsin-taurocholate-induced hemorrhagic acute pancreatitis, while in cerulein-induced edematous acute pancreatitis they did not rise in spite of a similar increase in immunoreactive trypsin. When rats in trypsin-taurocholate-induced pancreatitis were treated by protease inhibitor (FUT-175; nafamostat mesilate; FUT group), alpha 2M-T activity in serum was significantly lower than that in nontreated controls (mean +/- SEM, 20.8 +/- 1.43 U/L in the FUT group vs 79.1 +/- 24.5 in controls; p < 0.01). The survival rate at 24 h was significantly improved in the FUT group compared with the controls (70 vs 43%; p < 0.05). The increase in TAP concentration in the FUT group was similar to that in controls. The TAP concentration in pancreatic tissue at 24 h was significantly (p < 0.01) lower in the survival group (7.8 +/- 0.8 ng/ml) than in the lethal group (25.9 +/- 3.7 ng/ml). Activation of trypsinogen and its subsequent enzyme activity play an important role in the evolution of severe acute pancreatitis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caerulein,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proglumide,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cholecystokinin,
http://linkedlifedata.com/resource/pubmed/chemical/Taurocholic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsinogen,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-2-macroglobulin-trypsin...,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Macroglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/loxiglumide,
http://linkedlifedata.com/resource/pubmed/chemical/nafamostat,
http://linkedlifedata.com/resource/pubmed/chemical/trypsinogen activation peptide
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0885-3177
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-13
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7542773-Acute Disease,
pubmed-meshheading:7542773-Animals,
pubmed-meshheading:7542773-Caerulein,
pubmed-meshheading:7542773-Disease Models, Animal,
pubmed-meshheading:7542773-Guanidines,
pubmed-meshheading:7542773-Male,
pubmed-meshheading:7542773-Oligopeptides,
pubmed-meshheading:7542773-Pancreatitis,
pubmed-meshheading:7542773-Proglumide,
pubmed-meshheading:7542773-Protease Inhibitors,
pubmed-meshheading:7542773-Rats,
pubmed-meshheading:7542773-Rats, Wistar,
pubmed-meshheading:7542773-Receptors, Cholecystokinin,
pubmed-meshheading:7542773-Taurocholic Acid,
pubmed-meshheading:7542773-Trypsin,
pubmed-meshheading:7542773-Trypsinogen,
pubmed-meshheading:7542773-alpha-Macroglobulins
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pubmed:year |
1995
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pubmed:articleTitle |
Activation of trypsinogen in experimental models of acute pancreatitis in rats.
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pubmed:affiliation |
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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